Swinne D, Bogaerts J, Van de Perre P, Batungwanayo J, Taelman H
Laboratory of Mycology, Institute of Tropical Medicine, Antwerpen, Belgium.
Ann Soc Belg Med Trop. 1992 Dec;72(4):283-8.
To evaluate the latex test, two different retrospective studies were undertaken. A positive culture for Cr. neoformans was used as the golden standard of active cryptococcal infection. 439 sera selected at random sent to the NSP laboratory for screening of HIV antibody were tested as well as--71 CSF from patients with meningeal symptoms sent to the laboratory of the Centre Hospitalier de Kigali. In total, two discrepancies were found: two CSF samples from ancient cases of cryptococcosis under treatment were positive with the latex test and negative by culture. If it stands to reason that the antigen test cannot differentiate between active and inactive cryptococcal diseases, the persistence of small amounts of soluble antigens in a CSF implies that the patient must remain under surveillance, a relapse being very frequent in AIDS patients. As a conclusion, the latex test is a fast, easy to perform and quite reliable test for the diagnosis of cryptococcosis.
为评估乳胶试验，开展了两项不同的回顾性研究。新型隐球菌培养阳性被用作活动性隐球菌感染的金标准。随机选取439份送至国家血清学实验室筛查HIV抗体的血清以及71份来自基加利中心医院实验室、有脑膜症状患者的脑脊液进行检测。总共发现了两处差异：两份来自正在接受治疗的陈旧性隐球菌病病例的脑脊液样本，乳胶试验呈阳性而培养呈阴性。如果抗原试验无法区分活动性和非活动性隐球菌病是合理的，那么脑脊液中少量可溶性抗原的持续存在意味着患者必须持续接受监测，因为艾滋病患者复发非常频繁。总之，乳胶试验是一种快速、易于操作且诊断隐球菌病相当可靠的检测方法。
