Ward R J, Preedy V R
Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London, U.K.
Alcohol Alcohol. 1992 Nov;27(6):633-9.
Rats were chronically fed a nutritionally complete liquid diet containing 35% of total calories as either ethanol, or (for the controls) an isocaloric amount of glucose. After 6 weeks of treatment, the feeding regime induced skeletal muscle myopathy as characterised by reductions in muscle weight and RNA content. Ethanol preferentially affected the metabolically glycolytic plantaris (Type II fibre-predominant) muscle of the rat, compared with the metabolically oxidative soleus (Type I fibre-predominant). The changes in the plantaris were associated with increases in the concentration (mumol per g wet weight) of anserine (18%) and carnosine (50%). No significant changes were seen for the concentrations of either anserine or carnosine in the soleus muscle. The total contents (mumol per muscle) of carnosine and anserine in the plantaris were not significantly altered by ethanol treatment, though a significant decrease in anserine content (30%) occurred in the soleus. It is concluded that reductions in imidazole dipeptide content, considered to be antioxidants and/or intracellular buffering agents, are not mediating factors in the development of chronic experimental myopathy.
大鼠长期喂食营养完全的液体饮食，其中35%的总热量来源于乙醇，或（作为对照）等量热量的葡萄糖。治疗6周后，喂食方案诱发了骨骼肌肌病，其特征为肌肉重量和RNA含量降低。与代谢性氧化的比目鱼肌（以I型纤维为主）相比，乙醇优先影响大鼠代谢性糖酵解的跖肌（以II型纤维为主）。跖肌的变化与鹅肌肽浓度（每克湿重微摩尔数）增加18%和肌肽浓度增加50%有关。比目鱼肌中鹅肌肽或肌肽的浓度未见显著变化。乙醇处理后，跖肌中肌肽和鹅肌肽的总含量（每块肌肉微摩尔数）没有显著改变，尽管比目鱼肌中鹅肌肽含量显著降低了30%。得出的结论是，被认为是抗氧化剂和/或细胞内缓冲剂的咪唑二肽含量的降低，不是慢性实验性肌病发展的介导因素。
