Gabikian Patrik, Clatterbuck Richard E, Gailloud Philippe, Rigamonti Danielle
Department of Neurological Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7713, USA.
J Neurosurg. 2003 Aug;99(2):409-11. doi: 10.3171/jns.2003.99.2.0409.
Blue rubber-bleb nevus syndrome (BRBNS) is a developmental disorder that originally was identified by the presence of distinctive cutaneous and gastrointestinal hemangiomas. More recently it has been recognized that the number of affected organs is larger and that BRBNS includes central nervous system vascular malformations. A 52-year-old woman in whom intracranial vascular malformations had been diagnosed earlier presented for evaluation. At birth, several blue nevi had been noted on her tongue, lips, and neck. Cerebral angiography demonstrated an extensive network of developmental venous anomalies and a left anterior sinus pericranii. The literature on BRBNS and developmental venous anomalies is reviewed.
蓝色橡皮疱痣综合征（BRBNS）是一种发育障碍性疾病，最初是通过独特的皮肤和胃肠道血管瘤而被发现的。最近人们认识到，受影响的器官数量更多，并且BRBNS包括中枢神经系统血管畸形。一名52岁的女性，此前已被诊断患有颅内血管畸形，前来接受评估。出生时，在她的舌头、嘴唇和颈部发现了几个蓝色痣。脑血管造影显示有广泛的发育性静脉异常网络和左侧前颅骨膜窦。本文对BRBNS和发育性静脉异常的文献进行了综述。
