Hue B, Pelhate M, Callec J J, Chanelet J
C R Seances Soc Biol Fil. 1975;169(4):876-83.
Synaptic action of 4-aminopyridine (4-AP) has been studied in the sixth abdominal ganglion of the cockroach. Our results show that 4-AP has a strong excitatory effect on the ganglion and its seems that it depolarizes as well the pre and postsynaptic membranes. The threshold concentration is about 10(-5) M.