4-氨基吡啶对蟑螂第六腹神经节的突触后效应。
Postsynaptic effects of 4-aminopyridine in the sixth abdominal ganglion of the cockroach.
作者信息
Hue B, Pelhate M, Callec J J, Chanelet J
出版信息
Eur J Pharmacol. 1978 Jun 1;49(3):327-9. doi: 10.1016/0014-2999(78)90112-7.
PMID:658149
Abstract
The synaptic action of 4-aminopyridine (4-AP) was studied in the sixth abdominal ganglion of the cockroach Periplaneta americana L. The drug 4-AP did not modify the affinity of cholinergic receptors. At concentrations above 10(-4)M, 4-AP depolarized the postsynaptic membranes even after blockage of muscarinic and nicotinic receptors by antagonistic substances.
摘要
在美洲大蠊的第六腹神经节中研究了4-氨基吡啶（4-AP）的突触作用。药物4-AP不会改变胆碱能受体的亲和力。在浓度高于10^(-4)M时，即使在毒蕈碱和烟碱受体被拮抗物质阻断后，4-AP仍能使突触后膜去极化。
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