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从DNA序列数据估计适合度效应的分布：对分子钟的影响

Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.

作者信息

Piganeau Gwenaël, Eyre-Walker Adam

机构信息

Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10335-40. doi: 10.1073/pnas.1833064100. Epub 2003 Aug 18.

DOI:10.1073/pnas.1833064100
PMID:12925735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193562/
Abstract

We present a method for estimating the distribution of fitness effects of new amino acid mutations when those mutations can be assumed to be slightly advantageous, slightly deleterious, or strongly deleterious. We apply the method to mitochondrial data from several different species. In the majority of the data sets, the shape of the distribution is approximately exponential. Our results provide an estimate of the distribution of fitness effects of weakly selected mutations and provide a possible explanation for why the molecular clock is fairly constant across taxa and time.

摘要

我们提出了一种方法，用于估计新氨基酸突变的适应性效应分布，前提是这些突变可被假定为轻度有益、轻度有害或重度有害。我们将该方法应用于来自几个不同物种的线粒体数据。在大多数数据集中，分布形状近似指数分布。我们的结果提供了对弱选择突变适应性效应分布的估计，并为分子钟为何在不同分类群和时间内相当恒定提供了一种可能的解释。