人类胃癌中基因表达模式的变化。
Variation in gene expression patterns in human gastric cancers.
作者信息
Chen Xin, Leung Suet Y, Yuen Siu T, Chu Kent-Man, Ji Jiafu, Li Rui, Chan Annie S Y, Law Simon, Troyanskaya Olga G, Wong John, So Samuel, Botstein David, Brown Patrick O
机构信息
Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
Mol Biol Cell. 2003 Aug;14(8):3208-15. doi: 10.1091/mbc.e02-12-0833. Epub 2003 Apr 17.
Abstract
Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing approximately 30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
摘要
胃癌是全球第二大常见癌症死因。我们使用代表约30300个基因的cDNA微阵列，分析了90例原发性胃癌、14例转移性胃癌和22例非肿瘤性胃组织中的基因表达模式。胃癌与非肿瘤性胃组织在基因表达模式上存在特征性差异。我们发现胃癌中存在多种基因表达模式，这反映了肿瘤细胞和正常细胞内在特性的差异以及这些复杂组织细胞组成的差异。我们鉴定出了几个基因，其表达水平与患者生存率显著相关。不同患者癌症之间基因表达模式的差异提示了致病途径和潜在治疗策略的差异。
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