Safar M E
Department of Internal Medicine, Broussias Hospital, Paris, France.
Cardiovasc Drugs Ther. 1992 Dec;6(6):585-7. doi: 10.1007/BF00052559.
Publication of the SHEP study (Systolic Hypertension in the Elderly Programme) leaves no doubt that isolated systolic hypertension in the elderly should be treated. There are, however, a number of important outstanding questions: (a) the mechanism of reduction of morbidity, (b) because antihypertensive therapy appears to be more effective in elderly patients than in the young, when should treatment be started in relation to progression of age?, (c) besides the blood pressure elevation, what are the exact mechanical factors responsible for degeneration of the arterial wall?, and (d) what in 1993 is the definition of hypertension? These are questions that now need to be answered.
老年收缩期高血压计划（SHEP）研究的发表无疑表明，老年单纯收缩期高血压应接受治疗。然而，仍有一些重要的突出问题：（a）发病率降低的机制；（b）由于抗高血压治疗在老年患者中似乎比在年轻患者中更有效，那么相对于年龄增长，治疗应何时开始？（c）除血压升高外，导致动脉壁退变的确切力学因素是什么？以及（d）1993年高血压的定义是什么？这些都是现在需要回答的问题。
