神经母细胞瘤患者的水痘带状疱疹病毒感染：一项31年的临床研究。

Varicella zoster virus infections in neuroblastoma patients: a 31-year clinical study.

作者信息

Izbicki Tadeusz, Mazur Joanna, Izbicka Elzbieta

机构信息

Departments of Surgical Oncology and Epidemiology, National Research Institute of Mother and Child, Kasprzaka 17A Street, 01-211 Warsaw, Poland.

出版信息

Anticancer Res. 2003 May-Jun;23(3C):3061-8.

PMID:12926162

Abstract

BACKGROUND

The oncogenic potential of viruses was demonstrated in some human cancers. The oncogenic role of chickenpox (Cp) infection caused by varicella zoster virus has not been investigated to date.

PATIENTS AND METHODS

Among 333 children with neuroblastoma, 50 had Cp infection. The correlation of Cp infection with selected prognostic factors was analyzed.

RESULTS

One Cp patients was neuroblastoma stage I, 1-II, 2-IVS, 9-III and 37-IV. Cp was more frequent in stages III (18%) and IV (74%) than stages I + II + IVS (8%). The frequency of Cp in children < 2 years was 42% and > 2 years was 40%. The adrenal (42%) and extra-adrenal (40%) abdominal localizations were most common. The progression of neuroblastoma in stage IV occurred in 86.5% of Cp children in comparison to 43.6% of the population without Cp.

CONCLUSION

The risk of progression in neuroblastoma is higher in neuroblastoma children with Cp than in neuroblastoma patients without Cp.

摘要

背景

病毒的致癌潜力在某些人类癌症中得到了证实。水痘带状疱疹病毒引起的水痘（Cp）感染的致癌作用迄今尚未得到研究。

患者与方法

在333例神经母细胞瘤患儿中，50例有Cp感染。分析了Cp感染与选定预后因素的相关性。

结果

1例Cp感染患者为神经母细胞瘤I期，1例为I-II期，2例为2-IVS期，9例为III期，37例为IV期。Cp在III期（18%）和IV期（74%）比I + II + IVS期（8%）更常见。2岁以下儿童Cp感染率为42%，2岁以上儿童为40%。肾上腺（42%）和肾上腺外（40%）腹部定位最为常见。IV期神经母细胞瘤进展情况在Cp感染儿童中为86.5%，而在无Cp感染的人群中为43.6%。