Zolezzi P, Wenzel M S, Delgado M O
Instituto de Pediatría, Facultad de Medicina, Universidad Austral de Chile.
Rev Chil Pediatr. 1990 Mar-Apr;61(2):77-80.
Over a 10-year period, among 22 children with Hodgkin's disease (stages III and IV), 10 (45.5%) developed varicella-zoster virus (VZV) infection, varicella in 8 cases (36.4%) and herpes zoster (HZ) in 3 (13.6%) (one patient had varicella and six months later). Three patients with varicella had significant pneumonitis, one of them showed clinical evidence of dissemination and died. Two patients had localized HZ and one had disseminated HZ without visceral involvement. All cases of VZV infections occurred in the first year of treatment: the primary infection presented while patients were under induction therapy and the secondary one after radiotherapy.
在10年期间，22例霍奇金病（Ⅲ期和Ⅳ期）患儿中有10例（45.5%）发生水痘带状疱疹病毒（VZV）感染，其中8例（36.4%）为水痘，3例（13.6%）为带状疱疹（HZ）（1例患者先患水痘，6个月后发生带状疱疹）。3例水痘患者发生严重肺炎，其中1例有播散的临床证据并死亡。2例为局限性HZ，1例为无内脏受累的播散性HZ。所有VZV感染病例均发生在治疗的第一年：初次感染出现在患者诱导治疗期间，二次感染发生在放疗后。
