Consorti Fabrizio, Anello Attilio, Benvenuti Claudio, Boncompagni Andrea, Giovannone Gloria, Moles Nicola, Scardella Laura, Antonaci Alfredo
Dipartimento di Scienze Chirurgiche e Tecnologie Mediche Applicate-Università La Sapienza Roma, V.le del Policlinico, 00161 Roma, Italy.
Anticancer Res. 2003 May-Jun;23(3C):3089-92.
To confirm the predictive value of calcifications in thyroid nodules as a risk factor for malignancy and to detect aspects specific for tumours.
In a set of 196 patients (33 differentiated thyroid carcinoma, 9 follicular adenomas and 154 multinodular goiters with dominant nodule) calcifications were detected by ultrasound scan.
Calcifications were significantly more frequent in differentiated thyroid carcinoma (DTC) than in benign diseases (DTC 39.4%, adenoma 11.1%, goiter 20.1%) but their considered characteristics (size, number, position, location in the gland, sonographic features of the nodule) did not show any particular difference between DTC and benign diseases. The frequency of calcifications in our series was higher in older patients (mean age 59.4 +/- 13.7 vs. 52.1 +/- 13.1 in patients without calcifications, p < 0.001) and this could imply that their onset is time-dependent.
Calcifications can be a useful indicator of enhanced risk, to be considered in the overall diagnostic process.
确认甲状腺结节钙化作为恶性风险因素的预测价值，并检测肿瘤的特异性特征。
对196例患者（33例分化型甲状腺癌、9例滤泡性腺瘤和154例有主导结节的多结节性甲状腺肿）进行超声扫描检测钙化情况。
分化型甲状腺癌（DTC）中钙化的发生率显著高于良性疾病（DTC为39.4%，腺瘤为11.1%，甲状腺肿为20.1%），但其相关特征（大小、数量、位置、在腺体内的位置、结节的超声特征）在DTC和良性疾病之间未显示出任何特别差异。我们系列研究中钙化在老年患者中更常见（钙化患者平均年龄59.4±13.7岁，无钙化患者平均年龄52.1±13.1岁，p<0.001），这可能意味着其发生与时间相关。
钙化可作为风险增加的有用指标，应在整体诊断过程中予以考虑。
