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本文引用的文献

1
Mammographic density is related to stroma and stromal proteoglycan expression.乳腺钼靶密度与间质及间质蛋白聚糖表达有关。
Breast Cancer Res. 2003;5(5):R129-35. doi: 10.1186/bcr622. Epub 2003 Jul 23.
2
Heritability of mammographic density, a risk factor for breast cancer.乳腺密度的遗传力，乳腺癌的一个风险因素。
N Engl J Med. 2002 Sep 19;347(12):886-94. doi: 10.1056/NEJMoa013390.
3
A calibration approach to glandular tissue composition estimation in digital mammography.数字乳腺摄影中腺体组织成分估计的校准方法。
Med Phys. 2002 Aug;29(8):1867-80. doi: 10.1118/1.1493215.
4
Mammographic tissue, breast cancer risk, serial image analysis, and digital mammography. Part 2. Serial breast tissue change and related temporal influences.乳腺X线摄影组织、乳腺癌风险、序列图像分析与数字乳腺摄影。第2部分。乳腺组织的序列变化及相关时间影响因素。
Acad Radiol. 2002 Mar;9(3):317-35. doi: 10.1016/s1076-6332(03)80374-4.
5
Mammographic tissue, breast cancer risk, serial image analysis, and digital mammography. Part 1. Tissue and related risk factors.乳腺X线摄影组织、乳腺癌风险、序列图像分析与数字乳腺摄影。第1部分。组织及相关风险因素。
Acad Radiol. 2002 Mar;9(3):298-316. doi: 10.1016/s1076-6332(03)80373-2.
6
Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions.涉及上皮和基质的多步骤乳腺癌发生的遗传模型：肿瘤-微环境相互作用的线索
Hum Mol Genet. 2001 Sep 1;10(18):1907-13. doi: 10.1093/hmg/10.18.1907.
7
Effects of a short-term suspension of hormone replacement therapy on mammographic density.短期停用激素替代疗法对乳腺X线密度的影响。
Fertil Steril. 2001 Sep;76(3):451-5. doi: 10.1016/s0015-0282(01)01967-7.
8
Mammographic parenchymal patterns and breast cancer natural history--a case-control study.
Acta Oncol. 2001;40(4):461-5. doi: 10.1080/028418601750288172.
9
Risk factors for benign breast biopsies: a nested case-control study in the Alberta breast screening program.乳腺良性活检的风险因素：艾伯塔省乳腺筛查项目中的一项巢式病例对照研究。
Cancer Detect Prev. 2001;25(3):280-91.
10
Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention.乳腺钼靶密度作为人类乳腺癌风险的标志物及其在化学预防中的应用。
Curr Oncol Rep. 2001 Jul;3(4):314-21. doi: 10.1007/s11912-001-0083-7.

基质能为乳腺X线密度的细胞基础提供线索吗？

Can the stroma provide the clue to the cellular basis for mammographic density?

作者信息

Warren Ruth, Lakhani Sunil R

机构信息

Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

出版信息

Breast Cancer Res. 2003;5(5):225-7. doi: 10.1186/bcr642. Epub 2003 Jul 23.

DOI:10.1186/bcr642
PMID:12927028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC314441/
Abstract

Mammographic density is recognised as a useful phenotypic biomarker of breast cancer risk. Deeper understanding is needed of the cellular basis, but evidence is limited because of difficulty in designing studies to validate hypotheses. The ductal epithelial components do not adequately explain the physical and dynamic features observed. The stroma is thought to interact with ductal structures in cancer initiation. Stromal tissues might account for the mammographic features, and this interplay can be hypothesised to relate risk to density. In a paper in this issue of Breast Cancer Research, Alowami has shown a relationship between density and stromal proteins, which might provide useful insight into mammographic density.

摘要

乳腺密度被认为是乳腺癌风险的一种有用的表型生物标志物。需要对其细胞基础有更深入的了解，但由于难以设计研究来验证假设，相关证据有限。导管上皮成分无法充分解释所观察到的物理和动态特征。间质被认为在癌症发生过程中与导管结构相互作用。间质组织可能是乳腺钼靶特征的原因，并且可以假设这种相互作用将风险与密度联系起来。在本期《乳腺癌研究》的一篇论文中，阿洛瓦米展示了密度与间质蛋白之间的关系，这可能为乳腺钼靶密度提供有用的见解。