激活诱导的胞苷脱氨酶的表达在整个生命过程中会下降。
Expression of activation-induced cytidine deaminase decreases throughout the life.
作者信息
Radu D L, Kodera T, Bona C
机构信息
Department of Immunology, "Cantacuzino" National Institute for Microbiology and Immunology, Splaiul Independentei 103, Sector 5, Bucharest, Romania.
出版信息
J Cell Mol Med. 2003 Apr-Jun;7(2):141-5. doi: 10.1111/j.1582-4934.2003.tb00212.x.
Activation-induced cytidine deaminase (AID) is an RNA editing enzyme, which contributes to generation of new functional genes from a restricted number of genes of plant and animal genome. This enzyme was involved in the process of somatic mutation and class switching in vertebrate. Since the rate of somatic mutations is variable throughout ontogeny, we have studied the transcription of AID in 3 to 24 month-old Balb/c mice. Our results demonstrate a significant decrease of the transcription of the AID gene with aging. The decreased AID activity is not related to variation of phenotypic and functional properties of B cells throughout the life. This observation can explain the low rate of somatic mutation in aged animals.
激活诱导的胞苷脱氨酶（AID）是一种RNA编辑酶，它有助于从动植物基因组中有限数量的基因产生新的功能基因。这种酶参与了脊椎动物的体细胞突变和类别转换过程。由于体细胞突变率在整个个体发育过程中是可变的，我们研究了3至24月龄的Balb/c小鼠中AID的转录情况。我们的结果表明，随着年龄增长，AID基因的转录显著下降。AID活性的降低与B细胞在整个生命过程中的表型和功能特性变化无关。这一观察结果可以解释老年动物体细胞突变率较低的现象。
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