Tot Senel, Erdal M Emin, Yazici Kemal, Yazici Aylin Ertekin, Metin Ozmen
Department of Psychiatry, Mersin University Faculty of Medicine, Zeytinlibahçe cad, 33070 Mersin, Turkey.
Eur Psychiatry. 2003 Aug;18(5):249-54. doi: 10.1016/s0924-9338(03)00066-x.
This study aimed to investigate the possible association between T102C and -1438 G/A polymorphism in the 5-HT2A receptor gene and susceptibility to and clinical features of obsessive-compulsive disorder (OCD).
Fifty-eight patients with OCD and 83 healthy controls were included in the study. All patients were interviewed and rated by Yale-Brown Obsessive-Compulsive Scale. T102C and -1438 G/A polymorphisms of 5-HT2A receptor gene were determined by PCR technique in DNAs of peripheral leucocytes.
OCD patients and healthy controls did not show significant differences in genotype distribution for both polymorphisms investigated. We found that frequencies of the TT genotype for T102C polymorphism and the AA genotype for -1438 G/A polymorphism were significantly higher in patients with severe OCD compared to those with moderate or moderate-severe OCD.
The -1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD. Our data suggest that the TT genotype of T102C and the AA genotype of -1438 G/A polymorphism might be a factor in clinical severity of OCD.
本研究旨在探讨5-羟色胺2A受体基因中T102C和-1438 G/A多态性与强迫症（OCD）易感性及临床特征之间的可能关联。
本研究纳入了58例强迫症患者和83名健康对照者。所有患者均接受访谈，并采用耶鲁-布朗强迫症量表进行评分。通过聚合酶链反应（PCR）技术检测外周血白细胞DNA中5-羟色胺2A受体基因的T102C和-1438 G/A多态性。
在所研究的两种多态性的基因型分布上，强迫症患者和健康对照者之间未显示出显著差异。我们发现，与中度或中度-重度强迫症患者相比，重度强迫症患者中T102C多态性的TT基因型频率和-1438 G/A多态性的AA基因型频率显著更高。
5-羟色胺2A受体基因的-1438 G/A和T102C多态性与强迫症风险增加无关。我们的数据表明，T102C的TT基因型和-1438 G/A多态性的AA基因型可能是强迫症临床严重程度的一个因素。
