Isago Tsukasa, Nozaki Motohiro, Kikuchi Yuji, Honda Takashi, Nakazawa Hiroaki
Department of Plastic and Reconstructive Surgery,Tokyo Women's Medical University, Tokyo, Japan.
J Dermatol. 2003 Aug;30(8):596-601. doi: 10.1111/j.1346-8138.2003.tb00441.x.
Negative pressure dressings stimulate the healing of tissue-deficient wounds by applying continuous or intermittent negative pressure. This study was designed to determine the most effective negative pressure level for the reduction of the wound by using negative pressure dressings in animal studies. Fifty male Wister rats weighting 200-250 grams were used throughout the study. The animals were divided into five groups of ten animals each as follows: group 1: no negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. Group 2-5: 25, 50, 75 and 125 mmHg negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. The wounds were measured along the vertical and horizontal lengths of the body axis and the wound area was calculated. The reduction of the wound area was weaker in the group with a negative pressure of 25 mmHg, and similarly higher among the groups with negative pressures of 50, 75, or 125 mmHg. There were no significant differences in the reduction of the wound area among the latter three groups.
负压敷料通过施加持续或间歇性负压来刺激组织缺损伤口的愈合。本研究旨在通过在动物研究中使用负压敷料来确定减少伤口面积的最有效负压水平。在整个研究过程中使用了50只体重200 - 250克的雄性Wister大鼠。将动物分为五组，每组十只，分组如下：第1组：不施加负压，采用聚氨酯泡沫和粘性敷料的封闭敷料方法。第2 - 5组：分别施加25、50、75和125 mmHg负压，采用聚氨酯泡沫和粘性敷料的封闭敷料方法。沿着身体轴线的垂直和水平长度测量伤口，并计算伤口面积。在25 mmHg负压组中伤口面积的减小较弱，而在50、75或125 mmHg负压组中伤口面积减小程度较高。后三组在伤口面积减小方面没有显著差异。
