Kono Taro, Ercocen Ali Riza, Kikuchi Yuji, Isago Tsukasa, Honda Takashi, Nozaki Motohiro
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
J Dermatol. 2003 Jul;30(7):538-42. doi: 10.1111/j.1346-8138.2003.tb00429.x.
We report a combination procedure that can improve the effectiveness of laser removal of giant congenital melanocytic nevi (CMN). A 2-year-old girl with a giant CMN was seen in our outpatient clinic. Histological findings showed a compound nevus without any evidence of malignancy or dysplastic changes. The patient was treated with the normal mode ruby laser and Q-switched alexandrite laser. The lesion was significantly improved in color and cosmetic appearance. Partial hypopigmentation and texture changes were observed. Histological findings showed a marked decrease in the number of junctional melanocytes and the nests in the papillary and reticular dermis. The combined laser treatment is an effective method for the treatment of giant CMN, but further study is warranted to follow-up questions of recurrence and malignant change.
我们报告了一种联合治疗方法，该方法可提高激光去除巨大先天性黑素细胞痣（CMN）的效果。一名患有巨大CMN的2岁女孩在我们的门诊就诊。组织学检查结果显示为复合痣，无任何恶性或发育异常改变的迹象。该患者接受了常规模式红宝石激光和调Q紫翠宝石激光治疗。病变的颜色和外观有显著改善。观察到部分色素减退和质地改变。组织学检查结果显示交界性黑素细胞数量以及乳头层和网状真皮内的巢状结构明显减少。联合激光治疗是治疗巨大CMN的有效方法，但对于复发和恶变问题有必要进行进一步研究随访。
