Chen Dehan, Burmeister Lynn, Goldschlag Dan, Rosenwaks Zev
The Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, 505 East 70th Street, HMT-340, New York, NY 10021, USA.
Reprod Biomed Online. 2003 Jul-Aug;7(1):43-9. doi: 10.1016/s1472-6483(10)61727-0.
Ovarian hyperstimulation syndrome (OHSS) is a serious, iatrogenic complication of ovarian stimulation. The following report is a review of traditional and new strategies to prevent the development of OHSS. Techniques such as reducing the ovarian stimulus, coasting and cryopreservation are discussed. Other more investigative strategies are also summarized, including follicular aspiration, in-vitro maturation of immature oocytes, the use of gonadotrophin-releasing hormone (GnRH) agonists to trigger ovulation and the use of volume expanders such as hydroxyethyl starch. In addition, a review of the internal experience with OHSS at the authors' institution is described. All these preventative approaches are based on current understanding of the physiologic mechanisms involved in the pathogenesis of OHSS.
卵巢过度刺激综合征（OHSS）是卵巢刺激的一种严重医源性并发症。以下报告回顾了预防OHSS发生的传统和新策略。讨论了如减少卵巢刺激、周期取消和冷冻保存等技术。还总结了其他更多的研究策略，包括卵泡抽吸、未成熟卵母细胞的体外成熟、使用促性腺激素释放激素（GnRH）激动剂触发排卵以及使用羟乙基淀粉等容量扩张剂。此外，还描述了作者所在机构OHSS的内部经验回顾。所有这些预防方法均基于目前对OHSS发病机制中所涉及生理机制的理解。
