Escobedo A A, Cañete R, Gonzalez M E, Pareja A, Cimerman S, Almirall P
Departamento de Parasitología, Hospital Pediátrico Pedro Borrás, Calle F No. 616 esquina a 27, Plaza, Ciudad de La Habana, CP 10400, Cuba.
Ann Trop Med Parasitol. 2003 Jul;97(5):499-504. doi: 10.1179/000349803235002380.
To compare the efficacy of the two drugs in the treatment of giardiasis, 146 children (aged 5-15 years) with confirmed Giardia lamblia infection were randomly allotted to treatment with mebendazole (200 mg three times daily for 3 days) or secnidazole (30 mg/kg, in a single dose). Parasitological response to treatment was evaluated in each child by the microscopical examination of faecal samples collected 3, 5 and 7 days after he or she had completed treatment. Although the frequency of cure was higher for secnidazole (79.4%) than for mebendazole (78.1%), the difference was not statistically significant (P > 0.05). Both treatment regimens were well tolerated, with only mild, transient and self-limiting side-effects reported. Mebendazole may be preferable to secnidazole in the treatment of giardiasis cases who have an history of intolerance to 5-nitromidazoles, and where infections with Giardia and soil-transmitted helminths frequently co-occur.
为比较两种药物治疗贾第虫病的疗效，将146名确诊为蓝氏贾第鞭毛虫感染的儿童（5 - 15岁）随机分配接受甲苯达唑治疗（每日3次，每次200 mg，共3天）或塞克硝唑治疗（30 mg/kg，单次给药）。在每个儿童完成治疗后3、5和7天收集粪便样本进行显微镜检查，以评估治疗的寄生虫学反应。虽然塞克硝唑的治愈率（79.4%）高于甲苯达唑（78.1%），但差异无统计学意义（P > 0.05）。两种治疗方案耐受性均良好，仅报告有轻微、短暂且可自愈的副作用。在治疗对5 - 硝基咪唑类药物不耐受且贾第虫感染与土源性蠕虫感染常同时发生的贾第虫病病例时，甲苯达唑可能比塞克硝唑更可取。
