基因对大脑和行为的全身性唤醒的影响。
Genetic contributions to generalized arousal of brain and behavior.
作者信息
Garey J, Goodwillie A, Frohlich J, Morgan M, Gustafsson J-A, Smithies O, Korach K S, Ogawa S, Pfaff D W
机构信息
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11019-22. doi: 10.1073/pnas.1633773100. Epub 2003 Aug 20.
Abstract
We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-alpha), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-beta, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.
摘要
我们已经在小鼠行为中识别出一种全身性觉醒成分。通过跨实验、研究者和小鼠群体的数学/统计方法分析，它约占觉醒相关测量指标中变异的三分之一。编码经典雌激素受体（ER-α，一种配体激活转录因子）的基因敲除极大地降低了觉醒反应。相比之下，破坏一种可能是基因复制产物ER-β的基因则没有这些作用。在一种实验上易于处理的哺乳动物中，采用数学和遗传学方法相结合来研究觉醒，开启了对具有相当理论和实际意义的中枢神经系统功能的分析。
相似文献
1
Genetic contributions to generalized arousal of brain and behavior.基因对大脑和行为的全身性唤醒的影响。
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11019-22. doi: 10.1073/pnas.1633773100. Epub 2003 Aug 20.
2
How generalized CNS arousal strengthens sexual arousal (and vice versa).中枢神经系统兴奋如何增强性兴奋（反之亦然）。
Horm Behav. 2011 May;59(5):689-95. doi: 10.1016/j.yhbeh.2010.10.005. Epub 2010 Oct 13.
3
Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice.不依赖雌激素反应元件的雌激素受体（ER）-α信号传导不能挽救性行为，但可恢复雄性ERα基因敲除小鼠的正常睾酮分泌。
Endocrinology. 2007 Nov;148(11):5288-94. doi: 10.1210/en.2007-0673. Epub 2007 Aug 2.
4
Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice.雌激素受体α基因表达在雌性小鼠生殖相关行为中的作用。
Endocrinology. 1998 Dec;139(12):5070-81. doi: 10.1210/endo.139.12.6357.
5
Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice.雌激素受体-β基因缺失增强了雄性小鼠雌激素诱导的攻击性，但不影响性行为。
Eur J Neurosci. 2006 Apr;23(7):1860-8. doi: 10.1111/j.1460-9568.2006.04703.x.
6
Development of a sexually differentiated behavior and its underlying CNS arousal functions.性别分化行为及其潜在的中枢神经系统唤醒功能的发展。
Curr Top Dev Biol. 2007;79:37-59. doi: 10.1016/S0070-2153(06)79002-0.
7
Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects.基因敲除研究揭示的雌激素受体功能：神经内分泌和行为方面
Horm Behav. 1997 Jun;31(3):232-43. doi: 10.1006/hbeh.1997.1390.
8
The neurophysiology of sexual arousal.性唤起的神经生理学
Best Pract Res Clin Endocrinol Metab. 2007 Sep;21(3):445-61. doi: 10.1016/j.beem.2007.04.006.
9
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO).缺乏雌激素受体α和β（αβ ERKO）的小鼠雄性性行为缺失
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14737-41. doi: 10.1073/pnas.250473597.
10
Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice.雄性小鼠中雌激素受体α基因缺失对睾酮依赖性行为的影响
Endocrinology. 1998 Dec;139(12):5058-69. doi: 10.1210/endo.139.12.6358.
引用本文的文献
1
A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds.一个由脑桥中央灰质介导的分布式听觉网络是对警报声作出超快速觉醒反应的基础。
Curr Biol. 2024 Oct 21;34(20):4597-4611.e5. doi: 10.1016/j.cub.2024.08.020. Epub 2024 Sep 11.
2
The Arousal-motor Hypothesis of Dopamine Function: Evidence that Dopamine Facilitates Reward Seeking in Part by Maintaining Arousal.多巴胺功能的觉醒-运动假说：多巴胺通过维持觉醒来促进奖励寻求的证据。
Neuroscience. 2022 Sep 1;499:64-103. doi: 10.1016/j.neuroscience.2022.07.008. Epub 2022 Jul 16.
3
A Bridge between the Breath and the Brain: Synchronization of Respiration, a Pupillometric Marker of the Locus Coeruleus, and an EEG Marker of Attentional Control State.呼吸与大脑之间的桥梁：呼吸同步、蓝斑的瞳孔测量标记以及注意力控制状态的脑电图标记
Brain Sci. 2021 Oct 6;11(10):1324. doi: 10.3390/brainsci11101324.
4
An open-source, wireless vest for measuring autonomic function in infants.一种用于测量婴儿自主功能的开源无线背心。
Behav Res Methods. 2020 Dec;52(6):2324-2337. doi: 10.3758/s13428-020-01394-4.
5
Motivated state control in larval zebrafish: behavioral paradigms and anatomical substrates.幼体斑马鱼的动机状态控制：行为范式与解剖学基础
J Neurogenet. 2016 Jun;30(2):122-32. doi: 10.1080/01677063.2016.1177048. Epub 2016 Jun 13.
6
Arousal dynamics drive vocal production in marmoset monkeys.觉醒动力学驱动狨猴的发声。
J Neurophysiol. 2016 Aug 1;116(2):753-64. doi: 10.1152/jn.00136.2016. Epub 2016 Jun 1.
7
Generalized CNS arousal: An elementary force within the vertebrate nervous system.全身性中枢神经系统唤醒：脊椎动物神经系统中的一种基本力量。
Neurosci Biobehav Rev. 2016 Sep;68:167-176. doi: 10.1016/j.neubiorev.2016.05.014. Epub 2016 May 20.
8
Estrogens, androgens and generalized behavioral arousal in gonadectomized female and male C57BL/6 mice.去势雌性和雄性C57BL/6小鼠中的雌激素、雄激素与全身性行为唤醒
Physiol Behav. 2015 Aug 1;147:255-63. doi: 10.1016/j.physbeh.2015.04.053. Epub 2015 Apr 30.
9
The influence of age of onset and acute anabolic steroid exposure on cognitive performance, impulsivity, and aggression in men.发病年龄和急性合成代谢类固醇暴露对男性认知能力、冲动性及攻击性的影响。
Psychol Addict Behav. 2014 Dec;28(4):1096-104. doi: 10.1037/a0036482. Epub 2014 May 19.
10
Neuropeptidergic signaling partitions arousal behaviors in zebrafish.神经肽信号在斑马鱼觉醒行为中起分区作用。
J Neurosci. 2014 Feb 26;34(9):3142-60. doi: 10.1523/JNEUROSCI.3529-13.2014.
本文引用的文献
1
Statistical analysis of hormonal influences on arousal measures in ovariectomized female mice.
Horm Behav. 2002 Dec;42(4):414-23. doi: 10.1006/hbeh.2002.1832.
2
Afferents to the ventrolateral preoptic nucleus.投射至腹外侧视前核的传入神经。
J Neurosci. 2002 Feb 1;22(3):977-90. doi: 10.1523/JNEUROSCI.22-03-00977.2002.
3
Effects of estrogen on activity and fear-related behaviors in mice.雌激素对小鼠活动及恐惧相关行为的影响。
Horm Behav. 2001 Dec;40(4):472-82. doi: 10.1006/hbeh.2001.1716.
4
Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice.雌激素受体β基因缺陷小鼠的焦虑增加与突触可塑性
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12278-82. doi: 10.1073/pnas.221451898. Epub 2001 Oct 2.
5
Effects of the phytoestrogen coumestrol on locomotor and fear-related behaviors in female mice.植物雌激素香豆雌酚对雌性小鼠运动及恐惧相关行为的影响。
Horm Behav. 2001 Aug;40(1):65-76. doi: 10.1006/hbeh.2001.1660.
6
An integrative theory of prefrontal cortex function.前额叶皮质功能的整合理论
Annu Rev Neurosci. 2001;24:167-202. doi: 10.1146/annurev.neuro.24.1.167.
7
Statistical analysis of measures of arousal in ovariectomized female mice.
Horm Behav. 2001 Feb;39(1):39-47. doi: 10.1006/hbeh.2000.1632.
8
Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex.解析执行过程：前扣带回皮层的战略功能与评估功能
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1944-8. doi: 10.1073/pnas.97.4.1944.
9
Hypocretin (orexin) deficiency in human narcolepsy.人类发作性睡病中的下丘脑分泌素（食欲素）缺乏。
Lancet. 2000 Jan 1;355(9197):39-40. doi: 10.1016/S0140-6736(99)05582-8.
10
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.食欲素基因敲除小鼠的发作性睡病：睡眠调节的分子遗传学
Cell. 1999 Aug 20;98(4):437-51. doi: 10.1016/s0092-8674(00)81973-x.
Zotero 插件