Ding M, Odgaard A, Hvid I
Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
J Bone Joint Surg Br. 2003 Aug;85(6):906-12.
We obtained medial and lateral subchondral cancellous bone specimens from ten human post-mortem proximal tibiae with early osteoarthritis (OA) and ten normal age- and gender-matched proximal tibiae. The specimens were scanned by micro-CT and the three-dimensional microstructural properties were quantified. Medial OA cancellous bone was significantly thicker and markedly plate-like, but lower in mechanical properties than normal bone. Similar microstructural changes were also observed for the lateral specimens from OA bone, although there had been no sign of cartilage damage. The increased trabecular thickness and density, but relatively decreased connectivity suggest a mechanism of bone remodelling in early OA as a process of filling trabecular cavities. This process leads to a progressive change of trabeculae from rod-like to plate-like, the opposite to that of normal ageing. The decreased mechanical properties of subchondral cancellous bone in OA, which are due to deterioration in architecture and density, indicate poor bone quality.
我们从十例患有早期骨关节炎（OA）的人类尸体近端胫骨以及十例年龄和性别匹配的正常近端胫骨中获取了内侧和外侧软骨下松质骨标本。通过显微CT对标本进行扫描，并对三维微观结构特性进行量化。内侧OA松质骨明显更厚且呈明显的板状，但力学性能低于正常骨。尽管外侧OA骨标本没有软骨损伤迹象，但也观察到了类似的微观结构变化。小梁厚度和密度增加，但连通性相对降低，这表明早期OA中骨重塑的机制是填充小梁腔的过程。这个过程导致小梁从杆状逐渐变为板状，这与正常衰老过程相反。OA中软骨下松质骨力学性能下降，这是由于结构和密度恶化所致，表明骨质量较差。
