Yoganathan K, Rossant Christine, Ng Siewbee, Huang Yicun, Butler Mark S, Buss Antony D
MerLion Pharmaceuticals, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240.
J Nat Prod. 2003 Aug;66(8):1116-7. doi: 10.1021/np030146m.
Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one known compound, fuscin (3), have been isolated from the soil fungus Oidiodendron griseum. These compounds were found to compete effectively with macrophage inflammatory protein (MIP)-1 alpha for binding to human CCR5, an important anti HIV-1 target that interferes with HIV entry into cells. The structures of these compounds were elucidated by spectroscopic methods.
从土壤真菌灰色拟盘多毛孢（Oidiodendron griseum）中分离出了两种新化合物，10-甲氧基二氢褐菌素（1）和褐菌素（2），以及一种已知化合物，褐菌素（3）。发现这些化合物能有效地与巨噬细胞炎性蛋白（MIP）-1α竞争，以结合人CCR5，CCR5是一种重要的抗HIV-1靶点，可干扰HIV进入细胞。通过光谱方法阐明了这些化合物的结构。
