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来自深海真菌灰色胶孢炭疽菌UBOCC-A-114129的生物活性代谢产物

Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129.

作者信息

Navarri Marion, Jégou Camille, Bondon Arnaud, Pottier Sandrine, Bach Stéphane, Baratte Blandine, Ruchaud Sandrine, Barbier Georges, Burgaud Gaëtan, Fleury Yannick

机构信息

Université de Brest, EA 3882, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, IBSAM, 6 Rue de l'université, 29000 Quimper, France.

COrInt, UMR CNRS 6226 & Université de Rennes, 35043 Rennes, France.

出版信息

Mar Drugs. 2017 Apr 7;15(4):111. doi: 10.3390/md15040111.

DOI:10.3390/md15040111
PMID:28387732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5408257/
Abstract

Four bioactive compounds have been isolated from the fungus UBOCC-A-114129 cultivated from deep subsurface sediment. They were structurally characterized using a combination of LC-MS/MS and NMR analyses as fuscin and its derivatives (dihydrofuscin, dihydrosecofuscin, and secofuscin) and identified as polyketides. Albeit those compounds were already obtained from terrestrial fungi, this is the first report of their production by an species and by the deepest subseafloor isolate ever studied for biological activities. We report a weak antibacterial activity of dihydrosecofuscin and secofuscin mainly directed against Gram-positive bacteria (Minimum Inhibitory Concentration (MIC) equal to Minimum Bactericidal Concentration (MBC), in the range of 100 μg/mL). The activity on various protein kinases was also analyzed and revealed a significant inhibition of CDC2-like kinase-1 (CLK1) by dihysecofuscin.

摘要

从深层地下沉积物中培养出的真菌UBOCC - A - 114129中分离出了四种生物活性化合物。通过液相色谱 - 串联质谱（LC - MS/MS）和核磁共振（NMR）分析相结合的方法，对它们的结构进行了表征，确定为褐菌素及其衍生物（二氢褐菌素、二氢去氢褐菌素和去氢褐菌素），并鉴定为聚酮化合物。尽管这些化合物已从陆生真菌中获得，但这是首次报道它们由某一物种以及有史以来研究过的最深海底下分离物产生并具有生物活性。我们报告了二氢去氢褐菌素和去氢褐菌素主要针对革兰氏阳性菌的微弱抗菌活性（最低抑菌浓度（MIC）等于最低杀菌浓度（MBC），范围为100μg/mL）。还分析了它们对各种蛋白激酶的活性，结果显示二氢去氢褐菌素对细胞周期蛋白依赖性激酶2样激酶 - 1（CLK1）有显著抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/22ec756e9866/marinedrugs-15-00111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/947ca5cef0d5/marinedrugs-15-00111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/df850be211d4/marinedrugs-15-00111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/7d5f2331b711/marinedrugs-15-00111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/22ec756e9866/marinedrugs-15-00111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/947ca5cef0d5/marinedrugs-15-00111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/df850be211d4/marinedrugs-15-00111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/7d5f2331b711/marinedrugs-15-00111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de3/5408257/22ec756e9866/marinedrugs-15-00111-g004.jpg

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本文引用的文献

1
Fungal and Prokaryotic Activities in the Marine Subsurface Biosphere at Peru Margin and Canterbury Basin Inferred from RNA-Based Analyses and Microscopy.基于RNA分析和显微镜观察对秘鲁边缘和坎特伯雷盆地海洋次表层生物圈中真菌和原核生物活动的推断
Front Microbiol. 2016 Jun 9;7:846. doi: 10.3389/fmicb.2016.00846. eCollection 2016.
2
Deep Subseafloor Fungi as an Untapped Reservoir of Amphipathic Antimicrobial Compounds.深海海底真菌作为两亲性抗菌化合物的未开发宝库。
Mar Drugs. 2016 Mar 10;14(3):50. doi: 10.3390/md14030050.
3
Marine natural products.
海洋藻类内生真菌sp.培养提取物中细胞毒性次生代谢产物生产及凋亡诱导活性的物理化学参数优化
Front Pharmacol. 2021 Apr 26;12:542891. doi: 10.3389/fphar.2021.542891. eCollection 2021.
4
A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors.最近报道的海洋来源天然产物激酶抑制剂的系统评价。
Mar Drugs. 2019 Aug 23;17(9):493. doi: 10.3390/md17090493.
海洋天然产物。
Nat Prod Rep. 2016 Mar;33(3):382-431. doi: 10.1039/c5np00156k. Epub 2016 Feb 3.
4
A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.深海真菌衍生生物活性代谢产物的简要综述
Mar Drugs. 2015 Jul 23;13(8):4594-616. doi: 10.3390/md13084594.
5
Species richness and adaptation of marine fungi from deep-subseafloor sediments.来自深海海底沉积物的海洋真菌的物种丰富度与适应性
Appl Environ Microbiol. 2015 May 15;81(10):3571-83. doi: 10.1128/AEM.04064-14. Epub 2015 Mar 13.
6
Gene expression in the deep biosphere.深层生物圈中的基因表达。
Nature. 2013 Jul 11;499(7457):205-8. doi: 10.1038/nature12230. Epub 2013 Jun 12.
7
Ligerin, an antiproliferative chlorinated sesquiterpenoid from a marine-derived Penicillium strain.利格灵，一种从海洋来源的青霉属菌株中分离得到的具有抗增殖作用的氯化倍半萜。
J Nat Prod. 2013 Feb 22;76(2):297-301. doi: 10.1021/np3007364. Epub 2013 Jan 29.
8
Microbial extracellular enzymes and the marine carbon cycle.微生物细胞外酶与海洋碳循环。
Ann Rev Mar Sci. 2011;3:401-25. doi: 10.1146/annurev-marine-120709-142731.
9
Secondary metabolites of fungi from marine habitats.海洋生境真菌的次生代谢产物。
Nat Prod Rep. 2011 Feb;28(2):290-344. doi: 10.1039/c0np00061b. Epub 2011 Jan 12.
10
Culturability and secondary metabolite diversity of extreme microbes: expanding contribution of deep sea and deep-sea vent microbes to natural product discovery.极端微生物的可培养性和次生代谢多样性：深海和深海热液喷口微生物对天然产物发现的贡献不断扩大。
Mar Biotechnol (NY). 2011 Feb;13(1):1-11. doi: 10.1007/s10126-010-9294-y. Epub 2010 May 1.