Kuhl H, Kaplan H G, Taubert H D
Dtsch Med Wochenschr. 1976 Mar 5;101(10):361-4. doi: 10.1055/s-0028-1104089.
Effects on the secretion of gonadotropins by D-Ser (TBU)6-EA10-LH-RH were investigated in 7 male volunteers without known endocrine disturbances. One week after subcutaneous injection of 100 mug of LH-RH the probands were given 5 mug of the LH-RH analogue subcutaneously into the abdominal wall. LH, FSH and testosterone concentrations were estimated in the serum and compared with each other at varying intervals after each injection. LH-RH caused a marked increase of the LH content in serum after 20 minutes with a maximum after 40 minutes. The effect of the analogue occurred with a delay. After 40 minutes an LH level was reached which still persisted 6 hours later. Contrary to LH there were considerable individual differences in serum FSH levels. In the initial phase after injection of LH-RH and LH-RH analogue that increase of the FSH level in serum was almost parallel. However, the analogue showed a marked depot effect. Serum concentrations of testosterone showed no significant changes after administration of the releasing hormones. D-Ser(TBU)6-EA10-LH-RH is approximately 20 times effective as LH-RH. A dose of 5 mug is effective for 6-8 hours.
在7名无已知内分泌紊乱的男性志愿者中，研究了D - Ser（TBU）6 - EA10 - LH - RH对促性腺激素分泌的影响。在皮下注射100微克LH - RH一周后，给受试者在腹壁皮下注射5微克LH - RH类似物。测定血清中的LH、FSH和睾酮浓度，并在每次注射后的不同时间间隔相互比较。LH - RH注射后20分钟血清中LH含量显著增加，40分钟时达到最大值。类似物的作用出现延迟。40分钟时达到的LH水平在6小时后仍持续存在。与LH不同，血清FSH水平存在相当大的个体差异。在注射LH - RH和LH - RH类似物后的初始阶段，血清中FSH水平的升高几乎是平行的。然而，类似物显示出明显的长效作用。给予释放激素后，血清睾酮浓度无显著变化。D - Ser（TBU）6 - EA10 - LH - RH的效力约为LH - RH的20倍。5微克的剂量有效6 - 8小时。
