RNA，首个大分子催化剂：核糖体是一种核酶。

RNA, the first macromolecular catalyst: the ribosome is a ribozyme.

作者信息

Steitz Thomas A, Moore Peter B

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

出版信息

Trends Biochem Sci. 2003 Aug;28(8):411-8. doi: 10.1016/S0968-0004(03)00169-5.

DOI:10.1016/S0968-0004(03)00169-5

PMID:12932729

Abstract

Recently, the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with substrates have been determined. These have provided exciting new insights into the principles of RNA structure, the mechanism of the peptidyl-transferase reaction and early events in the evolution of this RNA-protein complex assembly that is essential in all cells. The structures of the large subunit bound to a variety of antibiotics explain the effects of antibiotic resistance mutations and provide promise for the development of new antibiotics.

摘要

最近，嗜盐嗜碱菌（Haloarcula marismortui）的大核糖体亚基及其与底物的复合物的原子结构已被确定。这些研究为RNA结构原理、肽基转移酶反应机制以及这种在所有细胞中都至关重要的RNA-蛋白质复合物组装进化早期事件提供了令人兴奋的新见解。与多种抗生素结合的大亚基结构解释了抗生素抗性突变的影响，并为新型抗生素的开发带来了希望。