在疾病的SCID小鼠-人肠道异种移植模型中，肿瘤坏死因子α是人类肠道阿米巴结肠炎中肠道炎症的关键介质。
Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease.
作者信息
Zhang Zhi, Mahajan Sajan, Zhang Xiaochung, Stanley Samuel L
机构信息
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
Infect Immun. 2003 Sep;71(9):5355-9. doi: 10.1128/IAI.71.9.5355-5359.2003.
Abstract
We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of amebic colitis. We found that blockade of TNF-alpha reduced inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytokine production but had less marked effects on inflammation and disease.
摘要
我们利用人肠道异种移植中的溶组织内阿米巴感染来研究白细胞介素-1（IL-1）和肿瘤坏死因子α（TNF-α）在阿米巴性结肠炎发病机制中的作用。我们发现，阻断TNF-α可减轻阿米巴感染中的炎症和肠道损伤，而抑制IL-1可减少细胞因子的产生，但对炎症和疾病的影响较小。
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本文引用的文献
1
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.IKK和核因子κB抑制的两面性：预防全身炎症，但肠道缺血再灌注后局部损伤增加。
Nat Med. 2003 May;9(5):575-81. doi: 10.1038/nm849. Epub 2003 Apr 7.
2
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease.抗肿瘤坏死因子治疗可恢复克罗恩病患者的肠道屏障功能。
Am J Gastroenterol. 2002 Aug;97(8):2000-4. doi: 10.1111/j.1572-0241.2002.05914.x.
3
Inflammatory bowel disease.炎症性肠病
N Engl J Med. 2002 Aug 8;347(6):417-29. doi: 10.1056/NEJMra020831.
4
IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.白细胞介素-1β转化酶（半胱天冬酶-1）在肠道炎症中的作用
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13249-54. doi: 10.1073/pnas.231473998. Epub 2001 Oct 23.
5
Amebic infection in the human colon induces cyclooxygenase-2.人类结肠中的阿米巴感染会诱导环氧化酶-2。
Infect Immun. 2001 May;69(5):3382-8. doi: 10.1128/IAI.69.5.3382-3388.2001.
6
Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis.具有白细胞介素-1β转换酶（ICE）活性的溶组织内阿米巴半胱氨酸蛋白酶可导致阿米巴病中的肠道炎症和组织损伤。
Mol Microbiol. 2000 Aug;37(3):542-8. doi: 10.1046/j.1365-2958.2000.02037.x.
7
Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine.上皮细胞引发的炎症在人类肠道阿米巴感染的早期组织损伤中起关键作用。
Gastroenterology. 1998 Dec;115(6):1446-53. doi: 10.1016/s0016-5085(98)70023-x.
8
Cytokines in inflammatory bowel disease.炎症性肠病中的细胞因子
World J Surg. 1998 Apr;22(4):382-9. doi: 10.1007/s002689900401.
9
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