流感嗜血杆菌中的烟酰胺核糖摄取突变体。
Nicotinamide ribosyl uptake mutants in Haemophilus influenzae.
作者信息
Herbert Mark, Sauer Elizabeta, Smethurst Graeme, Kraiss Anita, Hilpert Anna-Karina, Reidl Joachim
机构信息
Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom.
出版信息
Infect Immun. 2003 Sep;71(9):5398-401. doi: 10.1128/IAI.71.9.5398-5401.2003.
Abstract
The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.
摘要
在流感嗜血杆菌中鉴定出了烟酰胺核糖（NR）转运蛋白（pnuC）的基因。一个pnuC突变体仅具有残余的NR摄取能力，并且在高浓度NR的情况下能够在体外存活，但在体内无法存活。PnuC可能是开发预防流感嗜血杆菌疾病抑制剂的一个靶点。
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