小类核结合蛋白H-NS、HU和Fis影响鼠伤寒沙门氏菌中hilA的表达。
The small nucleoid-binding proteins H-NS, HU, and Fis affect hilA expression in Salmonella enterica serovar Typhimurium.
作者信息
Schechter Lisa M, Jain Sumita, Akbar Samina, Lee Catherine A
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Infect Immun. 2003 Sep;71(9):5432-5. doi: 10.1128/IAI.71.9.5432-5435.2003.
Abstract
hilA encodes an activator of Salmonella enterica serovar Typhimurium virulence genes and is transcriptionally modulated by environmental conditions. We show that H-NS represses hilA under low-osmolarity conditions. H-NS, HU, and Fis also appear to affect the derepression of hilA by HilD. Modulation of hilA by counteracting repressing and derepressing mechanisms may allow Salmonella serovar Typhimurium to regulate its virulence genes in response to different situations in vivo.
摘要
hilA编码鼠伤寒沙门氏菌毒力基因的一种激活因子，并且受环境条件的转录调控。我们发现，在低渗透压条件下，H-NS会抑制hilA。H-NS、HU和Fis似乎也会影响HilD对hilA的去抑制作用。通过对抗抑制和去抑制机制来调节hilA，可能使鼠伤寒沙门氏菌能够在体内根据不同情况调控其毒力基因。
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本文引用的文献
1
HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype.HilE与HilD相互作用，并对鼠伤寒沙门氏菌侵袭表型的hilA转录和表达起负调控作用。
Infect Immun. 2003 Mar;71(3):1295-305. doi: 10.1128/IAI.71.3.1295-1305.2003.
2
Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators.在没有负调控因子的情况下，鼠伤寒沙门氏菌侵袭基因激活因子hilA的转录需要HilD激活。
J Bacteriol. 2003 Jan;185(2):525-33. doi: 10.1128/JB.185.2.525-533.2003.
3
HU: promoting or counteracting DNA compaction?组蛋白：促进还是对抗DNA压缩？
FEBS Lett. 2002 Oct 9;529(2-3):151-6. doi: 10.1016/s0014-5793(02)03363-x.
4
Growing repertoire of AraC/XylS activators.不断增加的阿糖胞苷/木糖异构酶激活剂种类
J Bacteriol. 2002 Oct;184(20):5529-32. doi: 10.1128/JB.184.20.5529-5532.2002.
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DNA-binding activities of the HilC and HilD virulence regulatory proteins of Salmonella enterica serovar Typhimurium.肠炎沙门氏菌鼠伤寒血清型的HilC和HilD毒力调节蛋白的DNA结合活性。
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6
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Microbes Infect. 2001 Nov-Dec;3(14-15):1281-91. doi: 10.1016/s1286-4579(01)01488-5.
7
Hha is a negative modulator of transcription of hilA, the Salmonella enterica serovar Typhimurium invasion gene transcriptional activator.Hha是鼠伤寒沙门氏菌侵袭基因转录激活因子hilA转录的负调节因子。
J Bacteriol. 2001 Nov;183(22):6620-9. doi: 10.1128/JB.183.22.6620-6629.2001.
8
AraC/XylS family members, HilC and HilD, directly bind and derepress the Salmonella typhimurium hilA promoter.阿拉伯糖操纵子/木糖操纵子家族成员HilC和HilD直接结合并解除对鼠伤寒沙门氏菌hilA启动子的抑制。
Mol Microbiol. 2001 Jun;40(6):1289-99. doi: 10.1046/j.1365-2958.2001.02462.x.
9
Roles of hilC and hilD in regulation of hilA expression in Salmonella enterica serovar Typhimurium.hilC和hilD在鼠伤寒沙门氏菌中调控hilA表达的作用。
J Bacteriol. 2001 May;183(9):2733-45. doi: 10.1128/JB.183.9.2733-2745.2001.
10
Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression.Fis是一种与DNA类核相关的蛋白质，参与鼠伤寒沙门氏菌SPI-1侵袭基因的表达。
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