Mainio A, Hakko H, Niemelä A, Tuurinkoski T, Koivukangas J, Räsänen P
Department of Psychiatry, University of Oulu, Finland.
J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1278-82. doi: 10.1136/jnnp.74.9.1278.
The aim of this study was to investigate the level of anxiety in patients with a primary brain tumour and to analyse the effect of tumour laterality and histology on the level of anxiety. Recurrent measurements were assessed preoperatively, three months, and one year after operation.
The study population consisted of 101 patients with a primary brain tumour from unselected and homogeneous population in northern Finland. The patients were studied preoperatively with CT or MRI to determine the location of the tumour. The histology of the tumour was defined according to WHO classification. The level of anxiety was obtained by Crown-Crisp Experiential Index (CCEI) scale.
The patients with a tumour in the right hemisphere had statistically significantly higher mean anxiety scores compared to the patients with a tumour in the left hemisphere before surgery of the tumour. By three months and by one year after surgical resection of the tumour, the level of anxiety declined in patients with a tumour in the right hemisphere. A corresponding decline was not found in patients with a tumour in the left hemisphere. According to laterality by tumour histology, the level of anxiety decreased significantly in male and female patients with a glioma in the right hemisphere, but a corresponding decline was not significant in the female patients with a meningioma in the right hemisphere. Decreased level of anxiety was not found in patients with gliomas or meningiomas in the left hemisphere by follow up measurements.
Primary brain tumour in right hemisphere is associated with anxiety symptoms. The laterality of anxiety seems to reflect the differentiation of the two hemispheres. The level of anxiety declined after operation of right tumour, approaching that of the general population. The effect of right hemisphere gliomas on anxiety symptoms deserves special attention in future research.
本研究旨在调查原发性脑肿瘤患者的焦虑水平，并分析肿瘤位置和组织学对焦虑水平的影响。在术前、术后三个月和一年进行反复测量评估。
研究人群包括来自芬兰北部未经选择的同质人群中的101例原发性脑肿瘤患者。术前通过CT或MRI对患者进行研究以确定肿瘤位置。肿瘤组织学根据世界卫生组织分类进行定义。焦虑水平通过Crown-Crisp经验指数（CCEI）量表获得。
与肿瘤位于左半球的患者相比，肿瘤位于右半球的患者在肿瘤手术前的平均焦虑得分在统计学上显著更高。在肿瘤手术切除后的三个月和一年，右半球肿瘤患者的焦虑水平下降。左半球肿瘤患者未发现相应下降。根据肿瘤组织学的位置，右半球患有神经胶质瘤的男性和女性患者的焦虑水平显著下降，但右半球患有脑膜瘤的女性患者未出现相应显著下降。通过随访测量，左半球患有神经胶质瘤或脑膜瘤的患者未发现焦虑水平下降。
右半球原发性脑肿瘤与焦虑症状相关。焦虑的位置似乎反映了两个半球的差异。右半球肿瘤手术后焦虑水平下降，接近一般人群。右半球神经胶质瘤对焦虑症状的影响在未来研究中值得特别关注。
