Machetanz Kathrin, Wang Sophie S, Oberle Linda, Tatagiba Marcos, Naros Georgios
Department of Neurosurgery and Neurotechnology, Eberhard Karls University, 72074 Tuebingen, Germany.
Cancers (Basel). 2023 Sep 1;15(17):4365. doi: 10.3390/cancers15174365.
Vestibular schwannoma (VS) are equally common in men and woman. A number of epidemiological studies have reported on sex-specific aspects of incidence, tumor size, tinnitus and hearing loss. However, data on sex-specific, pre- and post-surgically quality of life (QoL) are rare. The objective of the present study was to determine sex-specific aspects on QoL in VS. Health-related QoL was analyzed in 260 patients (112 male/148 female) with unilateral sporadic VS using general (SF-36: general Short-Form Health Survey), disease-specific (PANQOL: Penn Acoustic Neuroma Quality-of-Life Scale, PANQOL) and symptom-specific (DHI: Dizziness Handicap Inventory; HHI: Hearing Handicap Inventory; THI: Tinnitus Handicap Inventory; FDI: Facial Disability Index) QoL questionnaires. Sex differences were evaluated pre- and postoperative by multi- and univariate analyses based on 200 preoperative and 88 postoperative questionnaires. Female patients were significantly more affected by dizziness, headaches, reduced energy and anxiety. Energy and balance changed similarly in both sexes after surgery. However, postoperative women tended to be more affected by facial palsy and headaches than men. Despite the greater physical impairment, general health improved equivalently or even more in female patients than in males. In conclusion, self-rated QoL in VS is significantly affected by sex and surgery. This should be taken into account when counseling VS patients regarding observation, radiotherapy, and surgery.
前庭神经鞘瘤（VS）在男性和女性中发病率相当。多项流行病学研究报告了发病率、肿瘤大小、耳鸣和听力损失等方面的性别差异。然而，关于性别特异性的术前和术后生活质量（QoL）的数据却很少。本研究的目的是确定VS患者生活质量的性别特异性方面。使用通用（SF-36：简明健康调查问卷）、疾病特异性（PANQOL：宾夕法尼亚听神经瘤生活质量量表）和症状特异性（DHI：头晕残障量表；HHI：听力残障量表；THI：耳鸣残障量表；FDI：面部残疾指数）生活质量问卷，对260例单侧散发性VS患者（112例男性/148例女性）的健康相关生活质量进行了分析。基于200份术前问卷和88份术后问卷，通过多变量和单变量分析对术前和术后的性别差异进行了评估。女性患者受头晕、头痛、精力下降和焦虑的影响明显更大。术后男女在精力和平衡方面的变化相似。然而，术后女性比男性更容易受到面瘫和头痛的影响。尽管身体损伤更大，但女性患者的总体健康状况改善程度与男性相当，甚至更好。总之，VS患者的自评生活质量受性别和手术的显著影响。在为VS患者提供观察、放疗和手术方面的咨询时，应考虑到这一点。
