Tracqui A, Kintz P, Wendling P, Ritter-Lohner S, Mangin P, Jaeger A
Institut de Médecine Légale, Strasbourg, France.
J Anal Toxicol. 1992 Nov-Dec;16(6):398-400. doi: 10.1093/jat/16.6.398.
A fatal case of acebutolol self-poisoning is presented. After single-step liquid-liquid alkaline extraction, acebutolol was identified by using an HPLC/DAD screening procedure. By means of a specific HPLC method, acebutolol was then quantified in a large range of postmortem samples. The blood acebutolol concentration was 34.7 micrograms/mL. The tissue distribution of the drug is discussed in the light of the existing literature.
本文报告了一例醋丁洛尔自服中毒致死的病例。经过单步液-液碱性萃取后，采用高效液相色谱/二极管阵列检测（HPLC/DAD）筛查程序对醋丁洛尔进行了鉴定。然后通过特定的高效液相色谱法对大量尸检样本中的醋丁洛尔进行了定量分析。血液中醋丁洛尔浓度为34.7微克/毫升。并结合现有文献对该药物的组织分布情况进行了讨论。
