Sangster B, de Wildt D, van Dijk A, Klein S
J Toxicol Clin Toxicol. 1983 Mar;20(1):69-77. doi: 10.3109/15563658308990051.
A case of a nonfatal acebutolol intoxication in a 15 year old female is described. Ingestion of 7600 mg acebutolol resulted in a plasma acebutolol concentration of 15 mg/1 one hour after ingestion. The patient remained conscious, had a severe hypotension and the electrocardiogram showed a 1st degree AV-block and severe intraventricular conduction disturbances at a rate of 70 bpm. After the administration of calcium gluconate and plasma the blood pressure gradually increased to normal values in 2 hours time. Plasma halflife of acebutolol was 8 hours. Pathophysiology of acebutolol intoxication is discussed.
本文描述了一名15岁女性非致命性醋丁洛尔中毒的病例。摄入7600毫克醋丁洛尔后1小时，血浆醋丁洛尔浓度达到15毫克/升。患者保持清醒，有严重低血压，心电图显示一度房室传导阻滞和严重室内传导障碍，心率为70次/分钟。给予葡萄糖酸钙和血浆后，血压在2小时内逐渐升至正常值。醋丁洛尔的血浆半衰期为8小时。文中讨论了醋丁洛尔中毒的病理生理学。
