Coleridge Smith Philip D
Department of Surgery, The Middlesex Hospital, London, UK.
Angiology. 2003 Jul-Aug;54 Suppl 1:S45-50. doi: 10.1177/0003319703054001s06.
The standard treatments for venous diseases of the lower limb include compression bandaging and stockings as well as surgical removal of varicose veins. There are a number of conditions in which these conventional treatments are ineffective, particularly in the management of leg ulceration. Drug treatments for healing venous leg ulcers have yet to be developed to the stage of good clinical efficacy, but these may assist in the management of patients. Flavonoid drugs have been widely used in the management of the symptoms of venous disease for many years and have recently been studied in some detail to assess their effects on the microcirculation. Work in animal models of ischemia-reperfusion show that MPFF (micronized purified flavonoid fraction) modulates leukocyte adhesion and prevents endothelial damage. Similar biochemical effects have been observed in patients with venous disease and may explain the efficacy of this drug in the management of edema and other symptoms of venous disease. There is clinical evidence that MPFF modifies venous leg ulcer healing.
下肢静脉疾病的标准治疗方法包括加压包扎和穿弹力袜，以及手术切除静脉曲张。在许多情况下，这些传统治疗方法无效，尤其是在治疗腿部溃疡方面。用于治愈下肢静脉溃疡的药物治疗尚未发展到具有良好临床疗效的阶段，但这些药物可能有助于患者的治疗。黄酮类药物多年来一直广泛用于治疗静脉疾病的症状，最近对其进行了一些详细研究，以评估它们对微循环的影响。在缺血再灌注动物模型中的研究表明，微粉化纯化黄酮组分（MPFF）可调节白细胞黏附并防止内皮损伤。在静脉疾病患者中也观察到了类似的生化效应，这可能解释了这种药物在治疗水肿和其他静脉疾病症状方面的疗效。有临床证据表明，MPFF可改善下肢静脉溃疡的愈合。
