Andrzejak R, Antonowicz J, Lewczuk E, Tomczyk J, Smolik R
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych AM, Wrocławiu.
Med Pr. 1992;43(5):411-20.
This paper presents the effects of combined exposure (noise, dust, nitrogen oxides) on the health condition of industrial workers, with special regard to red blood cell metabolism. 208 male industrial plant workers of the average age of 38.5 +/- 8.27 years and the average work period of 14.7 +/- 8.22 years were examined. The statistically significant increase of methemoglobin level was detected as well as some changes in erythrocyte metabolism in terms of increased activity of glucose-6-phosphate dehydrogenase, pyruvate kinase and in vitro production of lactic acid in erythrocytes. The observed changes indicate the influence of exposure to nitrogen oxides and the resulting cellular adaptation to unfavourable working conditions (activation of the pentose cycle and of the final stage of anaerobic glycolysis cycle).
本文介绍了联合暴露（噪声、粉尘、氮氧化物）对产业工人健康状况的影响，特别关注红细胞代谢。对208名男性产业工人进行了检查，他们的平均年龄为38.5±8.27岁，平均工作年限为14.7±8.22年。检测到高铁血红蛋白水平有统计学意义的升高，以及红细胞代谢方面的一些变化，表现为葡萄糖-6-磷酸脱氢酶、丙酮酸激酶活性增加，红细胞体外乳酸生成增加。观察到的这些变化表明氮氧化物暴露的影响以及由此产生的细胞对不利工作条件的适应（戊糖循环和无氧糖酵解循环最后阶段的激活）。
