Zlatev Z, Todorova K, Anastasova N, Chuturkova R, Yaneva A, Sabeva Y
Varna Branch of National Center of Hygiene Medical Ecology and Nutrition, HEI Varna, Bulgaria.
Int Arch Occup Environ Health. 1998 Sep;71 Suppl:S97-100.
The authors examined the influence of harmful factors of the working environment such as: microclimate, dust, noise, vibrations, and chemical noxes such as: ammonia, nitric oxides, hydrogen fluoride and gaseous fluorides, on the health status of workers involved in the production of fertilizers and ammonia in a nitrogen fertilizer plant. Various biochemical examinations of 158 workers were carried out. The morbidity rate for 1993-1995 was also studied. The biochemical monitoring indicated a statistically significant dependence of the abnormalities of the biochemical parameters on the professional exposure. The metabolic disturbances were proved by serum creatinine and urea elevations and rising urinary ammonia concentrations, by disturbances of the liver function consisting in an enhanced transaminase activity, and by disorders of the mineral metabolism presented with an increased urinary phosphorus excretion at a low serum phosphorus level as well as with increased serum and urinary fluorine concentrations. The temporarily registered morbidity rate showed a tendency towards an increase in diseases of the respiratory, gastrointestinal and cardiovascular system.
作者研究了工作环境中的有害因素，如：微小气候、粉尘、噪音、振动，以及化学毒物，如：氨、氮氧化物、氟化氢和气态氟化物，对氮肥厂参与化肥和氨生产的工人健康状况的影响。对158名工人进行了各种生化检查。还研究了1993 - 1995年的发病率。生化监测表明，生化参数异常与职业暴露之间存在统计学上的显著相关性。代谢紊乱表现为血清肌酐和尿素升高、尿氨浓度上升、肝功能紊乱导致转氨酶活性增强，以及矿物质代谢紊乱表现为血清磷水平低时尿磷排泄增加以及血清和尿氟浓度增加。临时记录的发病率显示，呼吸系统、胃肠道和心血管系统疾病有增加的趋势。
