Holly Elizabeth A, Eberle Carey A, Bracci Paige M
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA.
Am J Epidemiol. 2003 Sep 1;158(5):432-41. doi: 10.1093/aje/kwg174.
Data from a large population-based case-control study conducted in the San Francisco Bay Area between 1994 and 2001 were analyzed to examine the association between pancreatic cancer and history of allergic conditions. Pancreatic cancer cases (n = 532) had to be 21-85 years of age and were identified using rapid case ascertainment. Random digit dialing and Health Care Financing Administration lists (age, > or = 65 years) were used to obtain 1,701 controls who were frequency-matched to cases by sex and age within 5 years. In-person interviews were conducted and detailed allergy history data were obtained for all participants. Prior history of any allergy was associated with a reduced risk estimate for pancreatic cancer (odds ratio (OR) = 0.77, 95% confidence interval (CI): 0.63, 0.95). Inverse associations were observed for common allergens, including house dust (OR = 0.72, 95% CI: 0.54, 0.94), cats (OR = 0.59, 95% CI: 0.41, 0.85), plants (OR = 0.77, 95% CI: 0.62, 0.96), and mold (OR = 0.49, 95% CI: 0.32, 0.75), and for all allergic symptoms, although some confidence intervals included unity. Trends were observed for decreased risks associated with increasing number of allergies (p = 0.0006) and severity of allergic symptoms (p = 0.003). These results provide support for the plausibility that immune function in relation to allergies may play a role in the etiology of pancreatic cancer.
对1994年至2001年间在旧金山湾区开展的一项大型基于人群的病例对照研究的数据进行了分析，以检验胰腺癌与过敏病史之间的关联。胰腺癌病例（n = 532）年龄须在21至85岁之间，并通过快速病例确诊来识别。使用随机数字拨号和医疗保健财务管理局名单（年龄≥65岁）来获取1701名对照，这些对照按性别和年龄在5年内与病例进行频率匹配。对所有参与者进行了面对面访谈，并获取了详细的过敏史数据。任何过敏的既往史都与胰腺癌风险估计值降低相关（比值比（OR）= 0.77，95%置信区间（CI）：0.63，0.95）。对于常见过敏原，包括屋尘（OR = 0.72，95% CI：0.54，0.94）、猫（OR = 0.59，95% CI：0.41，0.85）、植物（OR = 0.77，95% CI：0.62，0.96）和霉菌（OR = 0.49，95% CI：0.32，0.75），以及所有过敏症状，均观察到反向关联，尽管一些置信区间包含1。观察到与过敏数量增加（p = 0.0006）和过敏症状严重程度增加（p = 0.003）相关的风险降低趋势。这些结果为与过敏相关的免疫功能可能在胰腺癌病因中起作用这一合理性提供了支持。
