Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Int J Cancer. 2018 May 15;142(10):2019-2027. doi: 10.1002/ijc.31241. Epub 2018 Jan 12.
Previous case-control studies have suggested that atopic allergic conditions (AACs) are inversely associated with pancreatic cancer, but this relationship has not been supported in many prospective settings. In this study, we investigated the influence of AACs (asthma, hay fever, or allergy) and the treatment of these conditions on pancreatic cancer risk among participants of the Multiethnic Cohort Study (MEC). AACs and antihistamine use were assessed via a baseline questionnaire when participants joined the MEC in 1993-1996. Risk ratios (RRs) and 95% confidence intervals (CIs) for pancreatic cancer incidence by AACs and antihistamines were calculated using Cox regression, adjusting for age, sex, ethnicity, education, smoking status, family history of pancreatic cancer, body mass index, diabetes, and alcohol intake. We further evaluated associations among subgroups defined by age, sex, ethnicity, follow-up time, and known pancreatic cancer risk factors. During an average 16-year follow-up, 1,455 incident cases of pancreatic cancer were identified among 187,226 white, African American, Latino, Japanese American, and Native Hawaiian men and women. AACs (RR 1.00, 95% CI 0.88-1.12) and antihistamines (RR 0.92, 95% CI 0.78-1.07) were not clearly associated with pancreatic cancer incidence. While these associations were also null for most subgroups, we did observe protective associations of AACs (RR 0.74, 95% CI 0.56-0.98) and antihistamines (RR 0.66, 95% CI 0.45-0.96) among the oldest participants (70+). Our results, in agreement with past prospective studies, suggest that AACs are not associated with pancreatic cancer in general, but the observed protective associations among the oldest age group may warrant future investigation.
先前的病例对照研究表明，特应性过敏状况（AACs）与胰腺癌呈负相关，但这一关系在许多前瞻性研究中并未得到证实。在这项研究中，我们调查了特应性过敏状况（哮喘、花粉热或过敏）以及这些疾病的治疗对参加多民族队列研究（MEC）的参与者的胰腺癌风险的影响。AACs 和抗组胺药物的使用情况通过参与者于 1993-1996 年加入 MEC 时的基线问卷进行评估。使用 Cox 回归计算胰腺癌发病率的风险比（RR）和 95%置信区间（CI），并根据年龄、性别、种族、教育程度、吸烟状况、胰腺癌家族史、体重指数、糖尿病和饮酒量进行调整。我们进一步评估了根据年龄、性别、种族、随访时间和已知的胰腺癌危险因素定义的亚组之间的关联。在平均 16 年的随访期间，在 187226 名白人、非裔美国人、拉丁裔、日裔美国人和夏威夷原住民男性和女性中，共发现 1455 例胰腺癌新发病例。AACs（RR 1.00，95%CI 0.88-1.12）和抗组胺药物（RR 0.92，95%CI 0.78-1.07）与胰腺癌发病率无明显关联。虽然这些关联在大多数亚组中也为零，但我们确实观察到 AACs（RR 0.74，95%CI 0.56-0.98）和抗组胺药物（RR 0.66，95%CI 0.45-0.96）与年龄最大的参与者（70 岁及以上）之间存在保护关联。我们的结果与过去的前瞻性研究一致，表明 AACs 总体上与胰腺癌无关，但在年龄最大的亚组中观察到的保护关联可能需要进一步研究。
