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两性畸形的外科治疗

Surgical management of ambiguous genitalia.

作者信息

Rangecroft L

机构信息

Department of Paediatric Surgery, The Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

出版信息

Arch Dis Child. 2003 Sep;88(9):799-801. doi: 10.1136/adc.88.9.799.

DOI:10.1136/adc.88.9.799
PMID:12937103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1719635/
Abstract

The surgical management of children born with ambiguous genitalia has always been difficult, subject to evolving attitudes and techniques, and at times controversial. Standard protocols have stressed the need for early diagnosis, gender assignment, and appropriate surgery in infancy.(1) In recent years some authors, backed by patient support groups, have claimed that such surgery is damaging or mutilating and, as it is essentially cosmetic, should not be performed until the fully informed consent of the patient could be obtained-that is, when the child becomes "Gillick competent".(2-)(4) There are, however, so many specific issues related to the different diagnostic groups that such a policy would seem to be too prescriptive.

摘要

对出生时生殖器模糊不清的儿童进行手术治疗一直都很困难,这受到不断变化的观念和技术的影响,有时还存在争议。标准方案强调了早期诊断、性别指定以及在婴儿期进行适当手术的必要性。(1)近年来,一些作者在患者支持团体的支持下声称,这种手术具有伤害性或致残性,而且由于其本质上是美容性的,在获得患者充分知情同意之前不应进行——也就是说,当孩子具备“吉利克能力”时。(2 - )(4)然而,与不同诊断组相关的具体问题太多了,以至于这样一项政策似乎过于苛刻。

相似文献

1
Surgical management of ambiguous genitalia.两性畸形的外科治疗
Arch Dis Child. 2003 Sep;88(9):799-801. doi: 10.1136/adc.88.9.799.
2
Surgical options in disorders of sex development (dsd) with ambiguous genitalia.性别发育障碍(DSD)伴生殖器模糊患者的手术选择。
Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):311-24. doi: 10.1016/j.beem.2009.10.004.
3
Ambiguous external genitalia in the newborn and prepubescent child.新生儿及青春期前儿童的外生殖器模糊不清。
JAMA. 1970 Apr 13;212(2):308-11.
4
The child with ambiguous genitalia.
Curr Probl Surg. 1972 Nov:1-64. doi: 10.1016/s0011-3840(72)80014-5.
5
[Congenital genital anomalies. Aspects of diagnostics and treatment].[先天性生殖器异常。诊断与治疗方面]
Medicina (Kaunas). 2003;39(2):105-13.
6
Ambiguous genitals and the choice of gender.生殖器模糊与性别选择
Acta Paediatr Acad Sci Hung. 1978;19(3):191-8.
7
Surgical management of neonates and children with ambiguous genitalia.新生儿及儿童两性畸形的外科治疗
Acta Paediatr Hung. 1990;30(1):111-21.
8
Effects of feminizing surgery for ambiguous genitalia - a novel scale for evaluation of cosmetic and anatomical results.两性畸形女性化手术的效果——一种评估外观和解剖学结果的新量表
Neuro Endocrinol Lett. 2009;30(2):262-7.
9
Surgical implications of pediatric endocrine disorders.小儿内分泌疾病的外科手术意义
Postgrad Med. 1981 May;69(5):37-40, 42, 44-5. doi: 10.1080/00325481.1981.11715748.
10
Gender eugenics? The ethics of PGD for intersex conditions.性别优生学?对性别发育异常进行 PGD 的伦理问题。
Am J Bioeth. 2013;13(10):29-38. doi: 10.1080/15265161.2013.828115.

引用本文的文献

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Ambiguous genitalia-A social dilemma in Bangladesh: A case report.两性畸形——孟加拉国的一个社会困境:一例病例报告
Int J Surg Case Rep. 2018;42:98-101. doi: 10.1016/j.ijscr.2017.11.067. Epub 2017 Dec 8.
2
Clinical, hormonal and radiological profile of 46XY disorders of sexual development.46XY性发育障碍的临床、激素及影像学特征
Indian J Endocrinol Metab. 2016 May-Jun;20(3):300-7. doi: 10.4103/2230-8210.179999.
3
A Novel Mutation in Human Androgen Receptor Gene Causing Partial Androgen Insensitivity Syndrome in a Patient Presenting with Gynecomastia at Puberty.人类雄激素受体基因的一种新突变导致一名青春期出现男性乳房发育的患者发生部分雄激素不敏感综合征。
J Clin Res Pediatr Endocrinol. 2016 Jun 5;8(2):232-5. doi: 10.4274/jcrpe.2637. Epub 2016 Apr 18.
4
Disorders of sex development.性发育障碍
Korean J Urol. 2012 Jan;53(1):1-8. doi: 10.4111/kju.2012.53.1.1. Epub 2012 Jan 25.
5
Ethical principles and recommendations for the medical management of differences of sex development (DSD)/intersex in children and adolescents.医学管理儿童和青少年性别发育差异(DSD)/间性的伦理原则和建议。
Eur J Pediatr. 2010 Jun;169(6):671-9. doi: 10.1007/s00431-009-1086-x. Epub 2009 Oct 20.

本文引用的文献

1
Objective cosmetic and anatomical outcomes at adolescence of feminising surgery for ambiguous genitalia done in childhood.儿童期进行的两性畸形女性化手术在青春期的客观美容和解剖学结果。
Lancet. 2001 Jul 14;358(9276):124-5. doi: 10.1016/S0140-6736(01)05343-0.
2
Gender assignment and reassignment in 46,XY pseudohermaphroditism and related conditions.
J Clin Endocrinol Metab. 1999 Oct;84(10):3455-8. doi: 10.1210/jcem.84.10.6099.
3
Feminizing genitoplasty for congenital adrenal hyperplasia: what happens at puberty?先天性肾上腺皮质增生症的女性化生殖器成形术:青春期会发生什么?
J Urol. 1999 May;161(5):1588-91.
4
The Vecchietti procedure for surgical treatment of vaginal agenesis: comparison of laparoscopy and laparotomy.用于阴道发育不全手术治疗的韦基耶蒂手术:腹腔镜检查与剖腹手术的比较
Int J Gynaecol Obstet. 1999 Feb;64(2):153-8. doi: 10.1016/s0020-7292(98)00244-6.
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Pediatric ethics and the surgical assignment of sex.
J Clin Ethics. 1998 Winter;9(4):398-410.
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Androgen insensitivity syndrome: a survey of diagnostic procedures and management in the UK.雄激素不敏感综合征:英国诊断程序与管理的调查
Arch Dis Child. 1997 Oct;77(4):305-9. doi: 10.1136/adc.77.4.305.
7
Complete androgen insensitivity syndrome: clinical and anatomopathological findings in 23 patients.完全性雄激素不敏感综合征:23例患者的临床及解剖病理学发现
Genet Couns. 1997;8(1):7-12.
8
Management of ambiguous genitalia in pseudohermaphrodites: new perspectives on vaginal dilation.两性畸形假两性畸形患者生殖器模糊的处理:阴道扩张的新观点
Fertil Steril. 1997 Feb;67(2):229-32. doi: 10.1016/s0015-0282(97)81902-4.
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Accidental penetrating cervical cord injury in a young child.
Pediatr Emerg Care. 1996 Dec;12(6):428-31. doi: 10.1097/00006565-199612000-00011.
10
Osteopenia as a feature of the androgen insensitivity syndrome.骨质减少作为雄激素不敏感综合征的一个特征。
Clin Endocrinol (Oxf). 1995 Dec;43(6):671-5. doi: 10.1111/j.1365-2265.1995.tb00533.x.