卡铂诱导的实验性细胞抑制性骨髓抑制期间造血调控机制

Mechanisms of regulation of hemopoiesis during experimental cytostatic myelosuppression induced by carboplatin.

作者信息

Dygai A M, Zhdanov V V, Zyuz'kov G N, Udut E V, Simanina E V, Gur'yantseva L A, Khrichkova T Yu, Stavrova L A, Epshtein O I, Sergeeva S A, Gol'dberg E D

机构信息

Institute of Pharmacology, Tomsk Research Center, Materia Medica Holding Research-and-Production Company, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2007 May;143(5):581-4. doi: 10.1007/s10517-007-0185-9.

DOI:10.1007/s10517-007-0185-9

PMID:18239772

Abstract

The mechanisms of suppression and recovery of the bone marrow erythroid stem were studied on the model of myelosuppression induced by administration of carboplatin in the maximum tolerated dose. Single administration of the cytostatic led to the development of long-term hypoplasia of hemopoiesis. Despite enhanced proliferation of erythroid precursor caused by increased erythropoietic activity of blood plasma and bone marrow cells, inhibition of cell maturation prevented recovery of the content of morphologically recognizable erythrokaryocytes in the bone marrow.

摘要

在以最大耐受剂量给予卡铂诱导骨髓抑制的模型上，研究了骨髓红系干细胞的抑制和恢复机制。单次给予细胞抑制剂导致长期造血功能低下。尽管血浆和骨髓细胞的促红细胞生成活性增加导致红系前体细胞增殖增强，但细胞成熟的抑制阻止了骨髓中形态学上可识别的红细胞核细胞含量的恢复。