Cabrine-Santos Marlene, dos Santos Vitorino Modesto, de Lima Marcus Aurelho, de Abreu Marta Elena Araújo, Lages-Silva Eliane, Ramírez Luís Eduardo
Departamento de Clínica Médica, Faculdade de Medicina do Triângulo Mineiro, 38025-440, Uberaba, MG, Brasil.
Mem Inst Oswaldo Cruz. 2003 Jun;98(4):523-8. doi: 10.1590/s0074-02762003000400018. Epub 2003 Aug 18.
Authors describe genitourinary changes in male hamsters infected and reinfected with Trypanosoma cruzi. Changes in genital organs have been described in human and in experimental chagasic infection. Genital dysfunctions in chronic chagasic patients affect ejaculation, libido and sexual potency, and testis biopsies may show arrested maturation of germ cells, oligozoospermia and azoospermia. Sixty-five male hamsters were inoculated and reinoculated with 2x10 trypomastigotes of T. cruzi VIC strain, and 22 non-infected animals constituted the control group. Animals were necropsied and fragments from testis, epididymis, seminal vesicle and bladder were collected and stained with hematoxylin-eosin. Peroxidase anti-peroxidase procedure was utilized to detect tissue parasitism. T. cruzi nests were found in testis, epididymis and seminal vesicle of these hamsters. Such parasitism plays a role in the origin of genital lesions observed in humans and laboratory animals during chronic chagasic infection.
作者描述了感染并再次感染克氏锥虫的雄性仓鼠的泌尿生殖系统变化。人类和实验性恰加斯病感染中均已描述了生殖器官的变化。慢性恰加斯病患者的生殖功能障碍会影响射精、性欲和性能力，睾丸活检可能显示生殖细胞成熟停滞、少精子症和无精子症。65只雄性仓鼠接种并再次接种了2×10个克氏锥虫VIC株的锥鞭毛体，22只未感染的动物构成对照组。对动物进行尸检，收集睾丸、附睾、精囊和膀胱的组织碎片，并用苏木精-伊红染色。采用过氧化物酶抗过氧化物酶方法检测组织中的寄生虫。在这些仓鼠的睾丸、附睾和精囊中发现了克氏锥虫巢。这种寄生虫感染在慢性恰加斯病感染期间人类和实验动物中观察到的生殖系统病变的起源中起作用。
