Yuan Zhaoxu
College of Optometry, State University of New York, 33 West 42nd Street, New York, NY 10036, USA.
Graefes Arch Clin Exp Ophthalmol. 2003 Oct;241(10):840-4. doi: 10.1007/s00417-003-0728-3. Epub 2003 Aug 23.
To evaluate the physical and cytological characters of carbon (C), titanium (T) surface-modified intraocular lenses (IOLs) in rabbit eyes.
Water contact angle in air of C, T-IOLs was measured by goniometer using the sessile drop method. Extracapsular cataract extraction (ECCE) and IOL implantation were performed in rabbit eyes. Cells adhering to IOLs were measured using the MIAS-2000 Computer Analyzer System at 12 months after operation. The diopters and resolution of C, T-IOLs were measured after 1 year of implantation.
Water contact angle in air of C, T-IOLs (80, 84.5 deg) were significant lower than that of PMMA-IOL (74.8 deg). C, T-IOLs became hydrophobic compared with PMMA-IOLs. C, T-IOLs did not change significantly in diopters and resolution after 1 year of implantation in rabbit eyes. There were fibroblasts, epitheloid cells, giant cells, lymphocyte cells and fibrous membrane attached to the surface of IOLs.
The optical characteristics of C, T-IOL) were stable in rabbit eyes after 1 year of implantation. The C, T-IOLs became hydrophobic compared with PMMA-IOLs. They also induced foreign body reactions similar to those seen with PMMA-IOLs in rabbit eyes.
评估碳（C）、钛（T）表面改性人工晶状体（IOL）在兔眼中的物理和细胞学特性。
采用静滴法，使用测角仪测量C、T人工晶状体在空气中的水接触角。在兔眼中进行囊外白内障摘除术（ECCE）和人工晶状体植入术。术后12个月，使用MIAS - 2000计算机分析仪系统测量附着在人工晶状体上的细胞。植入1年后测量C、T人工晶状体的屈光度和分辨率。
C、T人工晶状体在空气中的水接触角（80°、84.5°）显著低于PMMA人工晶状体（74.8°）。与PMMA人工晶状体相比，C、T人工晶状体变得疏水。在兔眼中植入1年后，C、T人工晶状体的屈光度和分辨率没有明显变化。人工晶状体表面附着有成纤维细胞、上皮样细胞、巨细胞、淋巴细胞和纤维膜。
植入1年后，C、T人工晶状体在兔眼中的光学特性稳定。与PMMA人工晶状体相比，C、T人工晶状体变得疏水。它们在兔眼中也引发了与PMMA人工晶状体类似的异物反应。
