Xu Heng, Chen You-cun, Zhou Hong, Ren Xiao-ming
Department of Chemistry, Anqing Normal College, Anqing 246011, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2002 Oct;22(5):767-9.
In this paper, a series of new polymers with grafted amino acids were synthesized. The purpose of the research is to develop a kind of polymer drugs with grafted amino acids for the treatment of some patients. The preparations of polyvinyl alcohol and amino acid were described by using inorganic acid as catalyst. The reaction methods were investigated in order to find the optimal conditions for the highest yield and purity. The copolymers were analysed and characterized by IR and 1HNMR. The result indicated that the reaction products were what we needed and the yield of the polymer of polyvinyl alcohol and glycine was higher than that of polyvinyl alcohol and alanine.
本文合成了一系列接枝氨基酸的新型聚合物。该研究的目的是开发一种用于治疗某些患者的接枝氨基酸聚合物药物。描述了以无机酸为催化剂制备聚乙烯醇和氨基酸的方法。研究了反应方法以找到获得最高产率和纯度的最佳条件。通过红外光谱（IR）和核磁共振氢谱（1HNMR）对共聚物进行了分析和表征。结果表明反应产物正是我们所需要的，聚乙烯醇与甘氨酸聚合物的产率高于聚乙烯醇与丙氨酸聚合物的产率。
