Bai D, Yang G, Yuan H, Li Y, Wang K, Shao H
Department of Oncology, Second Affiliated Hospital, Hubei Medical University, Wuhan 430071.
J Tongji Med Univ. 1999;19(4):300-3. doi: 10.1007/BF02886968.
Thirty-eight colorectal cancer patients were randomly assigned to treatment group, which took cimetidine in the perioperative period, and control group to which no drug was given. Twenty healthy volunteers served as normal controls. NK cells were measured by immunocytochemical technique. The results showed that NK percentages before treatment in both groups of patients were significantly lower than those in normal controls (P < 0.05). NK cell percentages at admission, before operation, on the 2nd and the 10th postoperative days were 14.84 +/- 4.41, 15.74 +/- 3.75, 17.21 +/- 3.69, 21.05 +/- 4.54, respectively, for the treatment group, and 15.00 +/- 2.77, 13.05 +/- 2.46, 14.21 +/- 2.19, 15.58 +/- 1.68, respectively, for control group. The difference was statistically significant (P < 0.01), suggesting that the perioperative administration of cimetidine could help restore NK cells in colorectal cancer patients.
38例结直肠癌患者被随机分为治疗组（围手术期服用西咪替丁）和对照组（未给予药物）。20名健康志愿者作为正常对照。采用免疫细胞化学技术检测自然杀伤细胞（NK细胞）。结果显示，两组患者治疗前的NK细胞百分比均显著低于正常对照组（P < 0.05）。治疗组入院时、手术前、术后第2天和第10天的NK细胞百分比分别为14.84±4.41、15.74±3.75、17.21±3.69、21.05±4.54，对照组分别为15.00±2.77、13.05±2.46、14.21±2.19、15.58±1.68。差异具有统计学意义（P < 0.01），表明围手术期给予西咪替丁有助于恢复结直肠癌患者的NK细胞。
