Adams W J, Morris D L, Ross W B, Lubowski D Z, King D W, Peters L
Department of Surgery, St George Hospital, Kogarah, New South Wales, Australia.
Aust N Z J Surg. 1994 Dec;64(12):847-52. doi: 10.1111/j.1445-2197.1994.tb04562.x.
Fifty consecutive patients undergoing resection of colorectal cancer were randomized to either receive cimetidine at a dose of 400 mg bd for a minimum of 5 pre-operative days, then intravenously for 2 postoperative days, or to act as controls. Baseline immune function was determined in all patients by in vitro testing of lymphocyte proliferation (LP) in response to mitogen, skin testing for cell mediated immunity (CMI) and measurement of lymphocyte subsets. Immune function was retested in both groups on the second postoperative day. In control patients the mean postoperative LP value was 41% of pre-operative levels (P < 0.0001) and the mean CMI reduced to 29% (P < 0.0001). Patients treated with cimetidine had no significant fall in these parameters. Numbers of T and natural killer (NK) cells fell after surgery in both groups, and B cell numbers were maintained in the cimetidine group. It is concluded that cimetidine reduces the immunosuppression that follows colonic resection.
五十名连续接受结肠直肠癌切除术的患者被随机分为两组，一组患者术前至少5天每天两次接受400毫克西咪替丁治疗，术后静脉注射2天；另一组作为对照组。通过体外检测淋巴细胞对有丝分裂原的增殖反应（LP）、进行细胞介导免疫（CMI）的皮肤试验以及测量淋巴细胞亚群，来测定所有患者的基线免疫功能。两组患者均在术后第二天重新检测免疫功能。对照组患者术后LP的平均数值为术前水平的41%（P<0.0001），CMI平均降至29%（P<0.0001）。接受西咪替丁治疗的患者这些参数无显著下降。两组患者术后T细胞和自然杀伤（NK）细胞数量均下降，而西咪替丁组的B细胞数量保持不变。得出的结论是，西咪替丁可减轻结肠切除术后的免疫抑制。
