Ponto Laura L Boles, Schultz Susan K
Department of Radiology, Positron Emission Tomography Imaging Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Ann Clin Psychiatry. 2003 Jun;15(2):109-19. doi: 10.1023/a:1024688326023.
The marketing of Ginkgo biloba extract (GBE) products is directed to the healthy, not diseased, population primarily for the promotion and maintenance of optimal brain function, not the treatment or prevention of any specific pathological state. However, recommendations are available for the use of GBE for a myriad of diseases that generally fall into one of three categories--cerebrovascular, peripheral vascular, or mitigation of tissue damage. The evidence for the pharmacological actions of GBE stem from one of three types of investigations--clinical studies in humans, pharmacological trials in animals, and in vitro studies. The purpose of this paper is to review the scientific literature on the central nervous system effects of GBE, with emphasis on the potential mechanisms of action. Limitations of the current scientific literature are highlighted and suggestions for future human and animal research directions are proposed.
银杏叶提取物（GBE）产品的营销主要针对健康人群而非患病群体，其目的主要是促进和维持最佳脑功能，而非治疗或预防任何特定的病理状态。然而，银杏叶提取物可用于多种疾病，这些疾病一般可分为三类——脑血管疾病、外周血管疾病或减轻组织损伤。银杏叶提取物药理作用的证据来自三种研究类型之一——人体临床研究、动物药理学试验和体外研究。本文的目的是综述关于银杏叶提取物对中枢神经系统影响的科学文献，重点关注其潜在作用机制。文中强调了当前科学文献的局限性，并提出了未来人体和动物研究方向的建议。
