Yang J R, Li Q P, Rao M R
Department of Cardiovascular Pharmacology, Nanjing Medical College.
Yao Xue Xue Bao. 1992;27(10):729-33.
The effects of praeruptorin C (Pra-C, 15 mg/kg, bid x 3 d, ip) on global myocardial ischemia and reperfusion were investigated in the isolated working rat hearts. The results at 35 min after reperfusion showed that as compared with the values before ischemia, AP, LVSP, +dP/dtmax, -dP/dtmax, LVEDP and T were recovered up to 80 +/- 19%, 82 +/- 16%, 78 +/- 21%, 85 +/- 11%, 136 +/- 77% and 133 +/- 21%, respectively. The corresponding parameters of Nifedipine (Nif, 60 micrograms/kg, bid x 3 d, ip) were 80 +/- 16%, 97 +/- 30%, 102 +/- 24%, 106 +/- 32%, 129 +/- 41% and 145 +/- 46%, respectively. The CF, SV and HR were recovered by 81 +/- 11%, 104 +/- 20% and 78 +/- 7% when using Pra-C and 86 +/- 11%, 106 +/- 25% and 82 +/- 11%, respectively, when using Nif. Additionally, in comparison of Pra-C and Nif with the ischemia group, the levels of creatine kinase released from cardiac cells decreased by 30% and 40%; while calcium accumulation in myocardial mitochondria were 41% and 46%, respectively. The study suggests that the protective effects of Pra-C on myocardial cells in the isolated working rat heart during myocardial ischemia are similar to those Nif.
在离体工作大鼠心脏中研究了前胡丙素（Pra-C，15mg/kg，每日两次，共3天，腹腔注射）对整体心肌缺血再灌注的影响。再灌注35分钟时的结果显示，与缺血前的值相比，主动脉压（AP）、左心室收缩压（LVSP）、左室内压最大上升速率（+dP/dtmax）、左室内压最大下降速率（-dP/dtmax）、左心室舒张末期压（LVEDP）和心率（T）分别恢复到80±19%、82±16%、78±21%、85±11%、136±77%和133±21%。硝苯地平（Nif，60μg/kg，每日两次，共3天，腹腔注射）的相应参数分别为80±16%、97±30%、102±24%、106±32%、129±41%和145±46%。使用Pra-C时，心输出量（CF）、每搏输出量（SV）和心率（HR）分别恢复了81±11%、104±20%和78±7%；使用Nif时，分别恢复了86±11%、106±25%和82±11%。此外，与缺血组相比，Pra-C和Nif使心肌细胞释放的肌酸激酶水平分别降低了30%和40%；而心肌线粒体中的钙蓄积分别为41%和46%。该研究表明，Pra-C对离体工作大鼠心脏在心肌缺血期间心肌细胞的保护作用与Nif相似。
