Jiang H, Rao M R
Research Division of Cardiovascular Pharmacology, Nanjing Medical College.
Yao Xue Xue Bao. 1993;28(1):1-5.
The protective effects of m-nifedipine (m-Nif) and nifedipine (Nif) were studied in isolated rat hearts subjected global ischemia and reperfusion. After global ischemia for 30 min followed by reperfusion for 10 min, left ventricular (LV) compliance and developed pressure (DP) were severely declined, LV stiffness constant was significantly increased (P < 0.01). Previous treatment with m-Nif or Nif prevented changes of LV compliance, stiffness constant and DP caused by ischemia and reperfusion. No marked difference in potency between m-Nif and Nif was observed.
研究了间硝苯地平（m-Nif）和硝苯地平（Nif）对经历全心缺血和再灌注的离体大鼠心脏的保护作用。在全心缺血30分钟后再灌注10分钟，左心室（LV）顺应性和舒张末压（DP）严重下降，LV僵硬度常数显著增加（P < 0.01）。预先用m-Nif或Nif处理可防止缺血和再灌注引起的LV顺应性、僵硬度常数和DP的变化。未观察到m-Nif和Nif在效力上有明显差异。
