• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

红花黄色素对自发性高血压大鼠的降压作用及其对血浆肾素活性和血管紧张素Ⅱ水平的影响

[Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level].

作者信息

Liu F, Wei Y, Yang X Z, Li F G, Hu J, Cheng R F

机构信息

Department of Pharmacology, Xin jing Medical College, Urümuqi.

出版信息

Yao Xue Xue Bao. 1992;27(10):785-7.

PMID:1293928
Abstract

Safflower yellow (SY) is a mixture of chalconoid compounds extracted from Carthamus tinctorius L. Ig SY 1-2 g.kg-1.d-1 lowered the blood pressure of spontaneously hypertensive rats (SHR), for about 1.86-3.86 kPa. Five weeks after administration of SY, the plasma renin activity and angiotensin II level diminished in the SHR experimental groups. These suggest that the decrease of blood pressure is mediated by the renin-angiotensin system.

摘要

红花黄色素(SY)是从红花中提取的查耳酮类化合物的混合物。若给予SY 1-2克/千克/天,可使自发性高血压大鼠(SHR)的血压降低约1.86-3.86千帕。给予SY五周后,SHR实验组的血浆肾素活性和血管紧张素II水平降低。这些表明血压降低是由肾素-血管紧张素系统介导的。

相似文献

1
[Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level].红花黄色素对自发性高血压大鼠的降压作用及其对血浆肾素活性和血管紧张素Ⅱ水平的影响
Yao Xue Xue Bao. 1992;27(10):785-7.
2
Pharmacological profile of valsartan, a non-peptide angiotensin II type 1 receptor antagonist. 1st communication: antihypertensive effects of valsartan in hypertensive models.缬沙坦(一种非肽类血管紧张素II 1型受体拮抗剂)的药理学特性。首次通讯:缬沙坦在高血压模型中的降压作用。
Arzneimittelforschung. 1997 May;47(5):604-12.
3
Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive rats.卡托普利对正常及高血压大鼠肾素-血管紧张素系统、氧化应激和内皮素的影响。
Hypertension. 2005 Oct;46(4):943-7. doi: 10.1161/01.HYP.0000174602.59935.d5. Epub 2005 Aug 8.
4
Antihypertensive properties of a new long-acting angiotensin converting enzyme inhibitor in renin-dependent and independent hypertensive models.一种新型长效血管紧张素转换酶抑制剂在肾素依赖性和非肾素依赖性高血压模型中的降压特性。
Arzneimittelforschung. 1995 Aug;45(8):853-8.
5
Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats.RB 105(一种新型血管紧张素转换酶和中性内肽酶双重抑制剂)对高血压大鼠的降压和利钠作用
J Pharmacol Exp Ther. 1995 Jan;272(1):343-51.
6
Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats.杜仲提取物对自发性高血压大鼠的降压作用。
J Ethnopharmacol. 2010 May 27;129(2):238-43. doi: 10.1016/j.jep.2010.03.019. Epub 2010 Mar 27.
7
Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats.肾神经在自发性高血压大鼠中γ-氨基丁酸诱导的降压作用中的作用。
Eur J Pharmacol. 2005 Nov 7;524(1-3):120-5. doi: 10.1016/j.ejphar.2005.09.020. Epub 2005 Oct 25.
8
[Renal tissue angiotensins during converting enzyme inhibition of angiotensin I in spontaneously hypertensive rat].[自发性高血压大鼠中血管紧张素转换酶抑制血管紧张素I时的肾组织血管紧张素]
Arch Mal Coeur Vaiss. 1997 Aug;90(8):1135-41.
9
Continuous inhibition of the renin-angiotensin system and protection from hypertensive end-organ damage by brief treatment with angiotensin II type 1 receptor blocker in stroke-prone spontaneously hypertensive rats.在易卒中自发性高血压大鼠中,通过1型血管紧张素II受体阻滞剂短期治疗持续抑制肾素-血管紧张素系统并预防高血压靶器官损伤。
Life Sci. 2005 Sep 16;77(18):2233-45. doi: 10.1016/j.lfs.2004.12.048.
10
Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats.血管紧张素转换酶和血管紧张素II 1型受体抑制剂可恢复自发性高血压大鼠的高血压性内括约肌。
J Pharmacol Exp Ther. 2006 Aug;318(2):725-34. doi: 10.1124/jpet.106.103366. Epub 2006 Apr 28.

引用本文的文献

1
Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway.羟基红花黄色素 A 通过抑制 JAK2/STAT1 通路的激活来减轻心肌缺血/再灌注损伤。
Int J Mol Med. 2019 Aug;44(2):405-416. doi: 10.3892/ijmm.2019.4230. Epub 2019 Jun 5.
2
Medical uses of (Safflower): a comprehensive review from Traditional Medicine to Modern Medicine.(红花)的医学用途:从传统医学到现代医学的全面综述
Electron Physician. 2018 Apr 25;10(4):6672-6681. doi: 10.19082/6672. eCollection 2018 Apr.
3
Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in L-NAME-Induced Hypertensive Rats via Restoration of eNOS and AT₁R Expression.
红花提取物与卡托普利对L-精氨酸甲酯诱导的高血压大鼠的协同降压作用:通过恢复内皮型一氧化氮合酶和血管紧张素Ⅱ1型受体表达实现
Nutrients. 2016 Feb 29;8(3):122. doi: 10.3390/nu8030122.
4
Hydroxysafflor yellow A (HSYA) from flowers of Carthamus tinctorius L. and its vasodilatation effects on pulmonary artery.红花黄色素 A(HSYA)来自红花 Carthamus tinctorius L.,并具有扩张肺动脉的作用。
Molecules. 2012 Dec 13;17(12):14918-27. doi: 10.3390/molecules171214918.
5
Neuroprotective effects of safflor yellow B on brain ischemic injury.红花黄色素B对脑缺血损伤的神经保护作用。
Exp Brain Res. 2007 Mar;177(4):533-9. doi: 10.1007/s00221-006-0705-2. Epub 2006 Sep 28.