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红花黄色素 A（HSYA）来自红花 Carthamus tinctorius L.，并具有扩张肺动脉的作用。

Hydroxysafflor yellow A (HSYA) from flowers of Carthamus tinctorius L. and its vasodilatation effects on pulmonary artery.

机构信息

College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China.

出版信息

Molecules. 2012 Dec 13;17(12):14918-27. doi: 10.3390/molecules171214918.

DOI:10.3390/molecules171214918
PMID:23519263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268686/
Abstract

Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).

摘要

红花在中国传统上被用于治疗脑血管和心血管疾病。红花的主要成分羟基红花黄色素 A（HSYA）以其多种生物活性而闻名。本研究采用大孔树脂吸附色谱法结合 Waters 高通量自动纯化系统从红花中分离出 HSYA，并通过大鼠肺动脉（PA）环张力研究检测其对肺动脉（PA）的舒张作用。结果表明，HSYA 通过激活肺动脉平滑肌细胞（PVSMCs）中的 KV 通道发挥血管舒张作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/90a043d0be20/molecules-17-14918-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/b647bff82003/molecules-17-14918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/09412b9dc17d/molecules-17-14918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/3700218a5bff/molecules-17-14918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/265cfa98821c/molecules-17-14918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/294119d064ec/molecules-17-14918-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/90a043d0be20/molecules-17-14918-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/b647bff82003/molecules-17-14918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/09412b9dc17d/molecules-17-14918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/3700218a5bff/molecules-17-14918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/265cfa98821c/molecules-17-14918-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/294119d064ec/molecules-17-14918-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fed/6268686/90a043d0be20/molecules-17-14918-g006a.jpg

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