Kaneki Keisuke, Kanouchi Hiroaki, Matsumoto Mitsuharu, Kawasaki Yasuaki, Akuzawa Masao, Oka Tatsuzo
Department of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University, Japan.
J Vet Med Sci. 2003 Jul;65(7):781-5. doi: 10.1292/jvms.65.781.
Perchloric acid-soluble protein (PSP) is a members of a new hypothetical family (YER057c/YJGF family) of small proteins with presently unknown function. The high degree of evolutionary conservation of these proteins reflect an involvement in basic cellular regulation. The expression of PSP was examined in rat hepatoma cell dRLh 84-beared rats. The tumor weight increased to 4.24 g at 3 weeks after the transplantation of hepatoma cells and hepatoma which has less differentiated characteristics were observed in rat liver. The expression of PSP in rat hepatoma was down regulated as compared with intact tissue. Thus the expression of PSP seems to be associated with the differentiation process in these transformed cells. On the other hand, some positive cells against the PSP-antibody were observed in the central region of tumor tissue by immunohistochemistry. These cells were shown to be the lymphocytes and the macrophages. The involvement of PSP to cellular growth and differentiation is discussed.
高氯酸可溶性蛋白（PSP）是一个新的假定的小蛋白家族（YER057c/YJGF家族）的成员，目前其功能尚不清楚。这些蛋白高度的进化保守性反映了它们参与基本的细胞调节。在携带大鼠肝癌细胞dRLh 84的大鼠中检测了PSP的表达。肝癌细胞移植后3周，肿瘤重量增加到4.24 g，在大鼠肝脏中观察到具有较少分化特征的肝癌。与完整组织相比，大鼠肝癌中PSP的表达下调。因此，PSP的表达似乎与这些转化细胞的分化过程有关。另一方面，通过免疫组织化学在肿瘤组织的中央区域观察到一些抗PSP抗体的阳性细胞。这些细胞被证明是淋巴细胞和巨噬细胞。本文讨论了PSP在细胞生长和分化中的作用。
