Knoring B E, Avetisian A O, El'kin A V, Kozhemiakin L A, Simbirtsev A S, Sakharova I Ia, Loginova G P, Pigareva N V, Levashev Iu N
Probl Tuberk Bolezn Legk. 2003(7):42-7.
The paper deals with the effect of glutoxim included into a preoperative preparation regimen on immunological parameters in patients with fibrocavernous pulmonary tuberculosis. On admission, all the patients had inadequate cellular immunity and activated humoral immunity. After termination of a course of glutoxim therapy, there was an increase in the baseline low values of lymphocytic proliferative activity, in the count of mature T lymphocytes, and in the production of IL-2 induced by phytohemagglutinin. At the same time the similar parameters remained unchanged in the control group. The drug exerted the most noticeable stimulating effect on cellular immunity in patients with a limited process. Glutoxim produced no noticeable effect on humoral immunity. The immunomodulating effect of glutoxim was followed by improvement of the clinical and X-ray pictures of the disease. In glutoxim-treated patients with baseline immunological disorders, progression was found to occur 1.5-2 times more infrequently than in the control group. Indications for the use of glutoxim in the treatment of tuberculosis are specified on the basis of the baseline immunological parameters of each patient.
本文探讨了术前准备方案中加入谷胱甘肽对纤维空洞型肺结核患者免疫参数的影响。入院时，所有患者的细胞免疫功能不足，体液免疫功能激活。谷胱甘肽治疗疗程结束后，淋巴细胞增殖活性的基线低值、成熟T淋巴细胞计数以及植物血凝素诱导的IL-2产生均有所增加。与此同时，对照组的类似参数保持不变。该药物对病变局限的患者的细胞免疫产生了最显著的刺激作用。谷胱甘肽对体液免疫没有明显影响。谷胱甘肽的免疫调节作用之后，疾病的临床和X线表现得到改善。在基线存在免疫紊乱的谷胱甘肽治疗患者中，病情进展的发生率比对照组低1.5至2倍。根据每位患者的基线免疫参数确定使用谷胱甘肽治疗结核病的指征。
